成纤维细胞生长因子受体各亚型与小鼠肺纤维化及衰老的关系

发布时间：2018-01-14 13:21

本文关键词：成纤维细胞生长因子受体各亚型与小鼠肺纤维化及衰老的关系　出处：《南方医科大学学报》2013年04期 　论文类型：期刊论文

【摘要】：目的观察成纤维细胞生长因子受体(FGFR)各亚型与肺组织的纤维化及衰老之间的关系。方法应用荧光定量聚合酶链反应方法,分别检测不同鼠龄的小鼠肺组织FGFR1-4的表达水平;同时,采用常规病理切片(HE染色和Masson染色)观察不同鼠龄小鼠肺组织的纤维化状况。结果(1)FGFR各亚型在小鼠肺组织中表达水平不均匀,FGFR2的含量高于其他几个亚型;(2)8月龄小鼠肺组织中FGFR亚型表达水平均显著低于5周龄小鼠肺组织中FGFR的表达;(3)8月龄的小鼠肺组织表现出肺纤维化的变化。结论小鼠肺组织中FGFR水平的下降可能与年龄的增加相关;不同年龄组均以FGFR2的含量为高;小鼠肺组织随着鼠龄增加呈现不同程度的纤维化,可能与FGFR的表达下降相关;提示FGFs/FGFR可能参与衰老的发生及肺纤维化调节。
[Abstract]:Objective to investigate the relationship between fibroblast growth factor receptor (FGFR) subtypes and pulmonary fibrosis and senescence. The expression of FGFR1-4 in lung tissues of mice of different ages was detected. At the same time. The lung fibrosis of mice of different ages was observed by HE staining and Masson staining. Results the expression of FGFR subtypes was not uniform in the lung tissues of mice. The content of FGFR2 was higher than that of other subtypes. The expression of FGFR subtypes in the lung tissues of 8-month-old mice was significantly lower than that of 5-week-old mice. Pulmonary fibrosis was observed in the lung tissue of mice aged 8 months. Conclusion the decrease of FGFR level in the lung tissue of mice may be related to the increase of age. The content of FGFR2 was higher in different age groups. The lung tissues of mice showed different degrees of fibrosis with the increase of age, which may be related to the decrease of FGFR expression. These results suggest that FGFs/FGFR may be involved in the development of aging and the regulation of pulmonary fibrosis.
【作者单位】：南方医科大学南方医院健康管理中心;
【基金】：广东省自然科学基金(S2012010009213)
【分类号】：R363
【正文快照】： 随着我国已经逐渐步入老龄化社会,肺纤维化这一年龄相关性疾病的发病率逐渐增加,成为影响老年人身体健康的重要原因之一。肺纤维化一经形成,治疗手段有限,效果不甚理想,副作用较大。肺纤维化的发生机制复杂,在诸多的参与肺纤维化发生过程的因子中,成纤维细胞生长因子(FGFs)家

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