自噬参与免疫应答调控的研究进展

发布时间：2018-03-18 14:58

  本文选题：自噬　切入点：参与　出处：《中国免疫学杂志》2013年07期 　论文类型：期刊论文

【摘要】：正细胞自噬(Autophagy)是真核生物中古老且进化保守的对细胞内物质进行周转的重要过程。最早由Ashford和Porten于1962年用电子显微镜观察人的肝细胞在加入高血糖素后出现的自食(Self-eat-ing)现象而被发现[1]。后来人们将该现象命名为自噬。其通过双层膜包裹部分胞浆和细胞内需要降解的细胞器、蛋白质等成分形成自噬体,后者随之与溶酶体融合形成自噬溶酶体,并最终将所包裹的内容物降解。
[Abstract]:Autophagyis is an ancient and evolutionarily conserved important process in eukaryotes for the turnover of intracellular substances. In 1962, Ashford and Porten first observed the occurrence of autophagyin in human hepatocytes with the addition of glucagon. The phenomenon of eating self-eat-ingwas discovered [1]. It was later named autophagy, which encapsulates part of the cytoplasm and organelles that need to be degraded in the cell through a bilayer membrane. The protein and other components form autophagy which fuses with lysosome to form autophagy and finally degrades the encapsulated contents.
【作者单位】： 浙江大学免疫研究所;
【基金】：浙江省重大科技专项重点社会发展项目(2009c13018)资助
【分类号】：R392.1
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本文编号：1630078