Notch信号通路对免疫细胞的调节作用

发布时间：2018-04-08 14:06

本文选题：Notch信号通路　切入点：固有免疫细胞　出处：《中国生物化学与分子生物学报》2013年12期

【摘要】：Notch家族是一组进化上高度保守的跨膜蛋白,可以广泛调节细胞的发育和分化.越来越多的研究发现,Notch信号通路可以通过调节多种免疫细胞的发育和功能来调节机体的免疫功能.本文综述了Notch家族的组成,其调控因素及其靶基因,Notch信号通路对造血干细胞、固有免疫细胞和适应性免疫细胞的调节作用以及Notch信号通路参与的免疫相关疾病.Notch信号通路对造血干细胞、巨噬细胞、树突状细胞、肥大细胞、T和B淋巴细胞的发育和功能的发挥都有重要的调节作用,并参与肿瘤、病毒感染、炎症反应和自身免疫疾病等免疫相关疾病的发生.
[Abstract]:Notch family is a group of highly conserved transmembrane proteins, which can regulate cell development and differentiation extensively.More and more studies have found that Notch signaling pathway can regulate the immune function by regulating the development and function of various immune cells.In this review, the composition of Notch family, its regulatory factors and its target gene Notch signaling pathway for hematopoietic stem cells were reviewed.Regulation of innate immune cells and adaptive immune cells and immune-related disease. Notch signaling pathway involved in Notch signaling pathway on hematopoietic stem cells, macrophages, dendritic cells,Mast cells play an important role in the development and function of T and B lymphocytes, and participate in immune-related diseases such as tumor, viral infection, inflammatory reaction and autoimmune diseases.
【作者单位】：南京农业大学动物科技学院;
【基金】：国家自然科学基金项目(No.31272454和No.31201808) 国家重点基础研究发展规划(973计划,No.2012CB124703) 教育部博士点基金(No.20110097120033)资助~~
【分类号】：R392.11

【参考文献】