吡喹酮对曼氏裂头蚴感染小鼠治疗效果的进一步研究

发布时间：2018-04-13 19:17

本文选题：裂头蚴病 + 小鼠　；参考：《中国病原生物学杂志》2013年08期

【摘要】：目的进一步研究吡喹酮对裂头蚴感染小鼠的治疗效果。方法将80只小鼠随机等分为10组,每只小鼠经口感染8条裂头蚴;1~5组小鼠分别在感染后1、2、4、6和8周应用吡喹酮治疗(总剂量2 800mg/体重kg,3次/d,疗程3d),治疗后1周剖杀;6~9组小鼠均在感染后1周以相同剂量吡喹酮进行治疗,分别在治疗后2、4、6和8周剖杀;第10组小鼠仅灌服蒸馏水,感染后第9周剖杀。检获裂头蚴,计算各组平均检获虫数和减虫率。结果裂头蚴感染后1、2、4、6和8周,小鼠应用吡喹酮治疗1周(1~5组)的减虫率分别为39.00%、18.00%、17.13%、14.00%和8.38%(P0.05);减虫率具有随感染后开始治疗时间的延迟而降低的趋势(P0.05)。小鼠感染裂头蚴后1周,应用吡喹酮治疗后1、2、4、6和8周(1、6~9组)的减虫率分别为39.00%、29.63%、18.75%、14.00%和6.25%(P0.05),减虫率具有随治疗后时间的延长而降低的趋势(P0.05)。感染裂头蚴后1~8周小鼠应用吡喹酮治疗和感染1周后小鼠应用吡喹酮治疗1~8周,减虫率变化趋势一致,即随感染后时间的延长而降低。结论吡喹酮对小鼠裂头蚴感染无明显疗效。
[Abstract]:Objective to study the therapeutic effect of praziquantel on mice infected with mitomycaria.Methods 80 mice were randomly divided into 10 groups.The mice of each group were treated with praziquantel for 6 and 8 weeks (total dose 2 800mg/ body weight 3 times / d, course of treatment 3 d, 1 week after treatment). After 1 week of treatment, all the mice in group 6 were treated with the same dose of praziquantel at 1 week after infection.Dose of praziquantel for treatment,The mice in group 10 were treated with distilled water only and killed at 9 weeks after infection.The average seizure number and worm reduction rate of each group were calculated.Results the worm reduction rates of mice treated with praziquantel for 1 week and 1 week after infection were 39. 00% and 18. 13% and 8. 38% respectively.The worm reduction rates of mice treated with praziquantel for 1 week and 8 weeks after treatment were 39.00 and 29.63%, respectively. The worm reduction rates were 14.00% and 6.25%, respectively. The worm reduction rate showed a tendency of decreasing with the prolongation of the time after treatment.Mice were treated with praziquantel for 1 ~ 8 weeks after infection and praziquantel for 1 ~ 8 weeks after infection.Conclusion praziquantel has no obvious effect on the infection of mouse mitomycaria.
【作者单位】：郑州大学医学院寄生虫学教研室;
【基金】：国家自然科学基金项目(No.81172612)
【分类号】：R383.2

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