前额叶皮层和纹状体的局域场电位编码奖励信息以及它们之间的有效性连接的研究

发布时间：2018-04-15 20:01

本文选题：前额叶皮层 + 纹状体　；参考：《华东理工大学》2017年硕士论文

【摘要】：前额叶皮层和纹状体是大脑内两个重要的区域,单细胞电生理记录实验已发现前额叶皮层和纹状体的神经元能够编码奖励信息,但不清楚这两个区域的局域场电位(local field potential,LFP)是否也能编码奖励信息。为研究这个问题,当猴子在进行一个奖励预测实验时,用多通道电极同时记录了前额叶皮层和纹状体的局域场电位。采用短时傅里叶变换,将记录的局域场电位转换为时、频域上的信号,比较不同奖励条件(大水和小水)下功率值的分布。结果发现大约40%的通道能够区分不同的奖励条件,并且小水条件下的功率值大于大水条件下的功率值;进一步发现局域场电位在β频段(14-30Hz)上的功率值差别最显著。说明前额叶皮层和纹状体的局域场电位能够有效地编码奖励信息,主要是在β频段,有助于进一步理解局域场电位在处理奖励信息过程的作用。同时,本文采用格兰杰预测的方法计算了前额叶皮层到纹状体和纹状体到前额叶皮层两个方向在刺激前后的连接系数,比较结果显示:大、小水条件下,刺激后的两个脑区之间的连接强度均增大,且纹状体到前额叶皮层方向的连接系数增幅高于前额叶皮层到纹状体方向,可能纹状体向前额叶皮层提供了更多的信息。
[Abstract]:The prefrontal cortex and striatum are two important regions of the brain. Single cell electrophysiological recording experiments have found that neurons in the prefrontal cortex and striatum encode reward information.However, it is not clear whether the local field potential LFPs in these two regions can also encode reward information.To study this problem, local field potentials in the prefrontal cortex and striatum were simultaneously recorded using multi-channel electrodes in a reward prediction experiment.Using short time Fourier transform (STFT), the recorded local field potential (LFS) is converted to time, and the signals in frequency domain are compared to compare the distribution of power values under different reward conditions (big water and small water).The results show that about 40% of the channels can distinguish different reward conditions, and the power value of small water is higher than that of large water, and the local field potential has the most significant difference in 尾 -band 14-30 Hz.It is suggested that the local field potential in the prefrontal cortex and striatum can effectively encode reward information, mainly in the 尾 band, which is helpful to further understand the role of local field potential in the process of processing reward information.At the same time, Granger prediction was used to calculate the connection coefficients between prefrontal cortex to striatum and striatum to prefrontal cortex before and after stimulation.The intensity of connection between the two brain regions increased after stimulation, and the increase of the connectivity coefficient between striatum and prefrontal cortex was higher than that between prefrontal cortex and striatum, which may provide more information for the former frontal cortex of striatum.
【学位授予单位】：华东理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R338

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