虚寒模型与临床阳虚病人生化指标的类比分析研究

发布时间：2018-05-02 16:27

本文选题：虚寒模型 + 阳虚病人　；参考：《时珍国医国药》2013年01期

【摘要】：目的运用主成分分析方法,比较分析虚寒动物模型和临床阳虚病人生物学指标上变化一致性,综合评价氢化可的松模拟的虚寒状态动物模型。方法选择正常和虚寒模型SD大鼠各30只,健康人和临床阳虚病人各30人,放免法测定血清皮质醇(CORT)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、促甲状腺素(TSH);血清生化酶试剂法测定血糖(GLU)、血清甘油三酯(TG)、胆固醇(TC)、总蛋白(TP)、白蛋白(ALB)、免疫球蛋白(IgG、IgM)、补体(C3、C4)、乳酸(LAC)等指标。将数据标准化后进行主成分分析,进一步比较各组分得分,并计算模拟度。结果虚寒动物模型在免疫系统、内分泌系统和物质能量代谢方面均和临床病人相似,其模拟临床的模拟度是60.3%。结论氢化可的松琥珀酸钠塑造的虚寒动物模型可一定程度上模拟临床的阳虚病人。
[Abstract]:Objective to compare and analyze the consistency of biological indexes between the animal model of deficiency cold and that of clinical patients with yang deficiency by principal component analysis (PCA), and to evaluate the animal model of deficiency cold simulated by hydrocortisone. Methods 30 SD rats with normal and cold deficiency models, 30 healthy persons and 30 clinical patients with yang deficiency were selected. Radioimmunoassay for the determination of serum cortisol cortisone, triiodothyronine (T3), thyroxine (T4), thyrotropin (T4), thyrotropin (TSHN), serum biochemical enzyme assay for the determination of blood glucose (GLU), serum triglyceride (TG), cholesterol (TCN), total protein (TP), Albumin (ALB), immunoglobulin (IgG), complement. C _ (3) C _ (4) C _ (4), lactic acid (lactic acid) and so on. After data standardization, principal component analysis (PCA) was carried out to further compare the scores of each component and calculate the simulation degree. Results the immune system, endocrine system and substance and energy metabolism of asthenia cold animal model were similar to those of clinical patients, and the simulated degree of clinical simulation was 60.3%. Conclusion Hydrocortisone sodium succinate can mimic the clinical Yang deficiency patients to some extent.
【作者单位】：河南农业大学农学院;北京中医药大学中药学院;
【基金】：国家重点基础研究发展计划“973”计划)资助项目(No.2007CB512605)
【分类号】：R-332;R241

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