大肠杆菌CFT073双拷贝pap操纵子动力学模型及致病机制研究

发布时间：2018-05-22 10:56

本文选题：大肠杆菌CFT + 致病机制　；参考：《生物物理学报》2013年02期

【摘要】：致病性大肠杆菌CFT073(uropathogenic Escherichia coli CFT073)是一种重要的人体病原菌。基因组学研究表明其负责表达P菌毛的pap操纵子存在不寻常的双拷贝现象,且两份拷贝具有一定的差异性。近年来,人们对P菌毛调控系统的分子调控机制获得了一定的认识,但pap操纵子的双拷贝机制及其生物学意义还有待于深入研究。作者首先对双拷贝pap操纵子的调控系统建立Markov链模型,进一步结合种群动力学方法,研究双拷贝相互作用对该菌株种群表型分布演化的影响。模拟结果表明,合作的双拷贝种群在更广泛的环境下具有更强的适应性,并有利于种群更快地建立生存优势。这一研究对致病菌有效感染宿主所采用的策略进行了定量分析,有助于进一步理解CFT073及类似致病菌的致病机制。
[Abstract]:Pathogenic Escherichia coli (CFT073(uropathogenic Escherichia coli CFT 073) is an important human pathogen. Genomics studies show that the pap operon responsible for the expression of P fimbriae has an unusual double copy phenomenon, and the two copies are different to some extent. In recent years, the molecular regulation mechanism of P pili regulatory system has been recognized, but the double copy mechanism of pap operon and its biological significance need to be further studied. The Markov chain model was established for the regulation system of double copy pap operon, and the effect of double copy interaction on the phenotypic distribution and evolution of the strain was studied with population dynamics method. The simulation results show that the cooperative double-copy population has stronger adaptability in a wider environment and helps the population to establish survival advantages more quickly. This study provides a quantitative analysis of the strategies used to effectively infect the host, which is helpful to further understand the pathogenicity mechanism of CFT073 and similar pathogens.
【作者单位】：北京大学工学院生物医学工程系;
【基金】：国家科技支撑计划项目(2012BAI06B02) 国家自然科学基金项目(30970667,11021463,61131003,91231119) “973”计划项目(2011CB707503) 北京大学本科生科研训练项目校长基金项目~~
【分类号】：R378

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