Rho激酶促进细胞凋亡作用机制的研究进展

发布时间：2018-06-25 12:19

本文选题：激酶 + 促进　；参考：《江苏医药》2013年12期

【摘要】：Rho激酶(ROCK)是小G蛋白Rho的下游效应因子,可能参与了细胞凋亡从发生到被吞噬清除的整个过程。一方面,ROCK通过其丰富的底物参与内源性和外源性途径对凋亡的激活,并与胞内其他信号通路产生广泛交联;另一方面,ROCK通过调控肌动蛋白-肌球蛋白骨架重组参与细胞皱缩、胞膜出泡及崩解等一系列细胞形态的改变。本文将对ROCK促凋亡的作用机制作一综述。
[Abstract]:Rho kinase (ROCK) is a downstream effector of small G protein Rho, which may participate in the whole process of cell apoptosis from occurrence to phagocytosis. On one hand, ROCK participates in the activation of endogenous and exogenous pathway to apoptosis through its rich substrates, and has extensive cross-linking with other intracellular signaling pathways; on the other hand, ROCK regulates myosculation. The recombinant protein myosin skeleton is involved in a series of cell morphologic changes, such as cell shrinkage, cell membrane bleb and disintegration. This article will make a review of the action mechanism of ROCK to promote apoptosis.
【作者单位】：南京军区南京总医院中西医结合科;南方医科大学南京临床医学院;
【分类号】：R329.2

【共引文献】