mTOR信号传导与能量感知及能量稳态的调控

发布时间：2018-07-10 00:43

本文选题：mTOR + 能量感知　；参考：《生理科学进展》2013年05期

【摘要】：哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR),作为一种高度保守的丝氨酸/苏氨酸蛋白激酶,通过感知能量稳态的变化来调节细胞周期进程和细胞生长。在大鼠实验中,下丘脑内的mTOR与多种摄食相关的神经递质如神经肽Y(nerve peptide Y,NPY)和刺鼠色蛋白相关蛋白(agouti-related protein,AGRP)等共定位,在调节食物摄取中起着至关重要的作用。除了中枢神经系统,外周组织如胃黏膜组织中mTOR信号通路相关蛋白与ghrelin、nesfatin-1等胃肠激素也有共定位现象,mTOR活性的变化会导致ghrelin、nesfatin-1表达量的改变,进而影响中枢神经系统调节食物摄取。此外,mTOR信号参与机体的糖脂代谢,与胰岛素抵抗和肥胖等的发生发展密切相关。所以,mTOR信号在能量感知以及调节机体能量稳态中具有重要作用,是肥胖和2型糖尿病等代谢性疾病治疗的新靶点。
[Abstract]:As a highly conserved serine / threonine protein kinase, the mammalian rapamycin target protein (mammalian target of rapamycin mTOR regulates cell cycle progression and cell growth by sensing changes in energy homeostasis. In the rat experiment, the co-localization of mTOR in hypothalamus with various neurotransmitters related to food intake, such as neuropeptide Y (nerve peptide and agouti-related protein associated protein (agouti-related), plays an important role in the regulation of food intake. In addition to the central nervous system, the changes of mTOR signaling pathway related proteins and ghrelin nesfatin-1 in peripheral tissues and ghrelin nesfatin-1 may lead to changes in the expression of ghrelin nnesfatin-1 and thus affect the regulation of food intake by the central nervous system. In addition, the signal of mTOR is involved in the metabolism of glucose and lipid, and is closely related to the occurrence and development of insulin resistance and obesity. Therefore, mTOR signal plays an important role in energy perception and regulation of energy homeostasis, and is a new target for the treatment of metabolic diseases such as obesity and type 2 diabetes.
【作者单位】：北京大学医学部基础医学院生理学与病理生理学系;
【基金】：国家自然科学基金(81030012,81170795)资助课题
【分类号】：R363

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