骨形态发生蛋白与血小板衍生性生长因子在骨形成中协同作用的研究进展
发布时间：2018-10-10 18:38
【摘要】：骨形成是成骨细胞和破骨细胞在多种因子存在的微环境中共同作用的结果。骨损伤早期,控制骨祖细胞诱导作用的各种生物化学因素和生物生理学因素起着重要作用,然而在后期促进骨改建的各种细胞因子起主要作用。新近研究表明:各生长因子通过刺激成骨细胞的增殖及其活性,调节局部骨形成作用,然而关于生长因子在调节成骨细胞代谢中的相互作用关系尚不完全清楚。在众多骨生长因子中,骨形态发生蛋白(BMPs)被公认是目前最强的骨诱导因子,而血小板衍生性生长因子(PDGF)对骨改建有双向调节作用,因此,进一步探究BMP和PDGF及其二者在骨形成中的作用意义深远。本文作者探索BMPs和PDGF的化学结构及生物学作用,阐述BMP与PDGF在骨形成中协调作用的明确性和复杂性。
[Abstract]:Bone formation is the result of the interaction of osteoblasts and osteoclasts in the microenvironment in which many factors exist. In the early stage of bone injury, various biochemical and biophysiological factors controlling the induction of bone progenitor cells play an important role. However, various cytokines that promote bone remodeling play a major role in the later stage of bone injury. Recent studies have shown that the growth factors regulate local bone formation by stimulating the proliferation and activity of osteoblasts, but the interaction of growth factors in the regulation of osteoblast metabolism is not completely clear. Among the many bone growth factors, bone morphogenetic protein (BMPs) is recognized as the strongest bone inducer at present, while platelet-derived growth factor (PDGF) has a bidirectional effect on bone remodeling. To further explore the role of BMP and PDGF in bone formation is of great significance. The authors explore the chemical structure and biological functions of BMPs and PDGF, and explain the clarity and complexity of the coordinated role of BMP and PDGF in bone formation.
【作者单位】： 吉林大学第二医院口腔科;
【基金】：吉林省科技厅基础处面上项目资助课题(201115097) 吉林省卫生厅基础研究项目资助课题(20115023)
【分类号】：R341
[Abstract]:Bone formation is the result of the interaction of osteoblasts and osteoclasts in the microenvironment in which many factors exist. In the early stage of bone injury, various biochemical and biophysiological factors controlling the induction of bone progenitor cells play an important role. However, various cytokines that promote bone remodeling play a major role in the later stage of bone injury. Recent studies have shown that the growth factors regulate local bone formation by stimulating the proliferation and activity of osteoblasts, but the interaction of growth factors in the regulation of osteoblast metabolism is not completely clear. Among the many bone growth factors, bone morphogenetic protein (BMPs) is recognized as the strongest bone inducer at present, while platelet-derived growth factor (PDGF) has a bidirectional effect on bone remodeling. To further explore the role of BMP and PDGF in bone formation is of great significance. The authors explore the chemical structure and biological functions of BMPs and PDGF, and explain the clarity and complexity of the coordinated role of BMP and PDGF in bone formation.
【作者单位】： 吉林大学第二医院口腔科;
【基金】：吉林省科技厅基础处面上项目资助课题(201115097) 吉林省卫生厅基础研究项目资助课题(20115023)
【分类号】：R341
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