Establishment of Xenotransplantation Model of Human CN-AML w

发布时间：2021-12-18 22:08

　　Patients with FLT3-ITDmut /NPM1 cytogenetically normal acute myeloid leukemia （CN-AML）, as high-risk molecular group in CN-AML, are associated with a worse prognosis than other CN-AML patients. It is beneficial to generate xenotransplantation model of FLT3-ITDmut /NPM1 CN-AML to better understand the pathogenesis and therapeutic strategies of such AML subtype. The purpose of present study was to establish the xenotransplantation model in NOD/SCID mice with FLT3-ITDmut /NPM1 CN-AML primary cells.... 

【文章来源】：Journal of Huazhong University of Science and Technology（Medical Sciences）. 2013,33(03)SCI

【文章页数】：6 页

【文章目录】：
1 MATERIALS AND METHODS
    1.1 Patient Samples
    1.2 Gene Analysis
    1.3 Transplantation of AML Cells into NOD/SCID Mice and Serial Transplantation
    1.4 Quantitation of Human AML Cells in NOD/SCID Mice
    1.5 Curative Effectiveness of Cytarabine for Serial Xenotransplantation Model
    1.6 Statistical Analysis
2 RESULTS
    2.1 Clinical Characteristics of Patients
    2.2 Monitoring of Engraftment in NOD/SCID Mice
    2.3 Assessment of Xenotransplantation Model with FLT3-ITDmut/NPM1-CN-AML in NOD/SCID Mice
    2.4 Serial Transplantation
    2.5 Effectiveness of Treatment to Serial Model
3 DISCUSSION



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