利用图论方法研究MCI患者脑功能网络的点介性

发布时间：2017-12-27 03:04

本文关键词：利用图论方法研究MCI患者脑功能网络的点介性　出处：《中国医学计算机成像杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的:利用图论方法探索轻度认知功能障碍(MCI)患者大脑各脑区点介性的异常改变。方法:采集13名MCI患者和17名正常老年人(NC)的大脑静息态BOLD-f MRI数据。采用SPM8和DPARSF软件包进行数据预处理;构建大脑功能网络,并计算Sparsity=0.18(网络收益最大)时90个脑区的点介性。采用双样本t检验分别比较两组90个脑区点介性的差异。结果:两组人额上回、岛叶、楔前叶、前扣带和旁扣带回等区域点介性较大;中央扣带回、右海马区、杏仁核、枕下回、左梭状回、豆状核和右颞中回等区域点介性较小。MCI患者右额上回、右岛叶、右梭状回、左缘上回、右角回和左中央旁小叶6个区域点介性显著高于正常老年(P0.05);右额下回鳃盖部、右辅助运动区和右舌回3个区域点介性显著低于正常老年(P0.05)。结论:MCI患者大脑多个区域信息传递能力发生了异常改变,提示在MCI的诊断与鉴别诊断中应重点关注这些区域。
[Abstract]:Objective: To explore the abnormal changes in the permittivity of the brain regions of the patients with mild cognitive impairment (MCI) by means of graph theory. Methods: the brain resting state BOLD-f MRI data of 13 MCI patients and 17 normal aged people (NC) were collected. SPM8 and DPARSF software packages are used to preprocess the data; the brain function network is constructed and the 90 brain regions are calculated at the time of Sparsity=0.18 (maximum net income). A double sample t test was used to compare the difference between two groups of 90 brain regions. Results: the two groups had larger mediating points, such as superior frontal gyrus, insular lobe, anterior wedge, anterior cingulate and lateral cingulate gyrus, and so on. The central cingulate gyrus, right hippocampus, amygdala, occipital gyrus, left fusiform gyrus, lenticular nucleus and right middle temporal gyrus were relatively small. MCI patients with right frontal gyrus, right insula, right fusiform gyrus, left supramarginal gyrus, right angular gyrus and left paracentral lobule in 6 regions of dielectric is significantly higher than the normal aged (P0.05); right inferior frontal operculum, right supplementary motor area and right lingual gyrus 3 area was significantly lower than that of normal dielectric properties the elderly (P0.05). Conclusion: abnormal changes have occurred in the information transfer ability of multiple regions of the brain of MCI patients, suggesting that these areas should be focused on in the diagnosis and differential diagnosis of MCI.
【作者单位】：上海市同济医院医学影像科;同济大学附属东方医院医学影像科;
【基金】：国家自然科学基金(81171297,81301200,81071201,81271552,91071201) 上海市科委重点项目(11JC1412000);上海市科委引导类项目(124119a5000) 上海市卫生系统重点项目(2013ZYJB0012) 上海申康临床科技创新项目(SHDC22015021)~~
【分类号】：R445.2;R749.1
【正文快照】： 轻度认知功能障碍(mild cognitive impairment,MCI)是指老年人出现轻度记忆或某项认知功能障碍,尚不足以诊断为痴呆的临床现象。MCI患者是发展为阿尔茨海默病(Alzheimer disease,AD)的高危人群,MCI的诊断、鉴别诊断和及时的干预治疗对减少MCI向AD转化具有重要意义[1]。许多研

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