孕期经历地震应激对成年子代执行及记忆功能的影响

发布时间：2018-01-10 06:05

本文关键词：孕期经历地震应激对成年子代执行及记忆功能的影响　出处：《中国神经精神疾病杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨孕期暴露于唐山地震对子代成年后执行和记忆功能的影响。方法研究对象为唐山开滦矿业集团职工,纳入其母亲妊娠时经历唐山地震者251名为地震暴露组,母亲于地震后次年相应时间妊娠即未经历唐山地震者341名为对照组,并根据地震时母亲妊娠时间将地震暴露组分为孕晚期地震暴露组、孕中期地震暴露组、孕早期地震暴露组。采用威斯康星卡片分类测验(Wisconsin card sorting test,WCST)测试执行功能,简易视觉空间记忆测验—修订版(brief visuospatial memory test-revised,BVMT-R)测试记忆功能。结果两组间WCST各指标无统计学差异(P0.05),地震暴露组BVMT-R总分低于对照组[(25.54±7.45)vs.(27.28±7.10),P0.01]。地震暴露组中,孕期与性别因素对WCST中非持续性错误数存在交互作用(P0.05),其中孕晚期地震暴露组男性较女性更高(P0.01)。孕期对BVMT-R总分主效应具有统计学意义(P0.05),孕晚期和孕中期地震暴露组低于孕早期地震暴露组(均P0.05),但性别主效应及孕期和性别的交互作用均没有统计学意义(P0.05)。结论唐山地震对孕中期(4~6个月)和孕晚期(7~9个月)胎儿成年后的记忆功能具有潜在影响,孕晚期男性子代成年后执行功能较同期遭受地震应激的女性子代稍差。
[Abstract]:Objective to investigate the effect of Tangshan earthquake exposure during pregnancy on the executive and memory function of offspring after adulthood. Methods the object of study was workers of Tangshan Kailuan Mining Group. There were 251 pregnant women who had experienced Tangshan earthquake and 341 mothers who had not experienced Tangshan earthquake in the year after the earthquake. According to the pregnant time of the mother during the earthquake, the earthquake exposure group was divided into the late pregnant group and the second trimester group. Early pregnancy earthquake exposure group. Wisconsin card sorting test (WCST) was used to test the executive function. Brief visuospatial memory test-revised. Results there was no significant difference in WCST indexes between the two groups (P 0.05). The total BVMT-R score of earthquake exposure group was lower than that of control group. [T = 25.54 卤7.45 vs.f.27.28 卤7.10 (P0.01). In the earthquake exposure group. There was interaction between pregnancy and sex factors on the number of non-persistent errors in WCST (P0.05). In the late pregnancy earthquake exposure group, the male was higher than the female (P 0.01). The main effect of pregnancy on the total score of BVMT-R was statistically significant (P 0.05). The earthquake exposure group in late pregnancy and middle pregnancy was lower than that in early pregnancy (P 0.05). But there was no significant difference in the main effect of sex and the interaction between pregnancy and sex. Conclusion the Tangshan earthquake has a significant effect on the second trimester of pregnancy (4 ~ 6 months) and the third trimester of pregnancy (7 ~ 9 months). Fetal memory in adulthood has a potential effect. The executive function of male offspring in late pregnancy was slightly worse than that of female offspring exposed to earthquake stress in the same period.
【作者单位】：河北医科大学第一医院精神科河北医科大学精神卫生研究所河北省脑老化与认知神经科学重点实验室;开滦精神卫生中心;
【基金】：国家自然科学基金面上项目(编号:81271489) 河北省科技支撑重大项目(编号:09276103D) 河北省自然科学基金面上项目(编号:H2014206280)
【分类号】：R749
【正文快照】： ☆国家自然科学基金面上项目(编号:81271489);河北省科技支撑重大项目(编号:09276103D);河北省自然科学基金面上项目(编号:H2014206280)河北医科大学第一医院精神科,河北医科大学精神卫生研究所,河北省脑老化与认知神经科学重点实验室(石家庄050031)△开滦精神卫生中心高媛媛*

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