壳聚糖磷脂酰胆碱对痴呆大鼠学习能力和海马区白细胞介素-1β表达的影响

发布时间：2018-01-13 22:16

本文关键词：壳聚糖磷脂酰胆碱对痴呆大鼠学习能力和海马区白细胞介素-1β表达的影响　出处：《中国老年学杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的观察壳聚糖磷脂酰胆碱对治疗经海马内注射Aβ25~35的健康Wistar大鼠所诱导的阿尔茨海默病(AD)大鼠海马内白细胞介素(IL)-1β的表达数量以及该药物对AD大鼠学习记忆能力的干预疗效。方法对健康Wistar大鼠经两侧海马内注射Aβ25~35诱导建立AD大鼠炎性痴呆模型,Morris水迷宫以及免疫组织化学方法分别观察AD模型大鼠经药物治疗前后学习记忆能力以及海马内炎性表达因子IL-1β的表达状况。结果对照组和药物组大鼠的平均逃避潜伏期(AEL)比AD模型组显著缩短、2 min内跨越原平台次数和在靶象限时间比模型组明显延长(P0.05)。模型组大鼠海马区IL-1β阳性量高于对照组(P0.01),药物组IL-1β阳性表达较模型组显著下降(P0.05)。结论壳聚糖磷脂酰胆碱对改善AD大鼠学习记忆能力和注射Aβ25~35后诱导的炎性反应均有一定的治疗作用。
[Abstract]:Objective To observe the effect of chitosan phosphatidylcholine on the treatment of the health Wistar in the hippocampus of rats injected with A beta 25~35 induced Alzheimer's disease (AD) in hippocampus of rat interleukin (IL) -1 expression and the number of drugs on learning and memory ability of AD rats. Methods the health intervention effect of Wistar after both sides of intrahippocampal injection of A beta 25~35 induced inflammatory disease model of AD rats, Morris water maze and immunohistochemistry were observed in AD rats after drug treatment before and after the learning and memory abilities and hippocampal expression of inflammatory factor IL-1 beta expression status. The drug group and the control group of rats on average the escape latency (AEL) was significantly shorter than the AD model group, 2 min across the platform in the original times and in the target quadrant time was significantly longer than that of the model group (P0.05). The model group in hippocampus of IL-1 rat beta positive was higher than that of the control group (P0.01), drug group IL-1 The positive expression of beta was significantly lower than that in the model group (P0.05). Conclusion chitosan phosphatidylcholine has certain therapeutic effects on improving learning and memory ability and inflammatory reaction induced by A 25~35 25~35 in AD rats.

【作者单位】：菏泽医学专科学校护理系基础护理学教研室;
【分类号】：R749.16
【正文快照】： 阿尔茨海默病(AD)病因较为复杂,特征性的病理学改变是发生神经原纤维缠结(NFT)、大量老年斑(SP)形成以及神经元的丢失〔1〕。然而,现今仍缺乏有效的防治药物以及有效的治疗手段。近些年来,有研究表明,大脑内部的炎症反应在AD的发生发展中起着非常重要的作用〔2,3〕。因此,抑制

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