心率变异性在老年抑郁症中的变化及意义

发布时间：2018-01-16 01:14

本文关键词：心率变异性在老年抑郁症中的变化及意义　出处：《中国老年学杂志》2015年08期 　论文类型：期刊论文

【摘要】：目的研究老年抑郁症患者24 h动态心电图(DCG)心率变异性(HRV)的变化及意义。方法用三道生理记录仪分别对31例老年抑郁患者抗抑郁治疗前后、28例无心理障碍患者DCG波形进行记录。将检出DCG进行HRV时域和频域分析。结果抑郁症组31例HRV时域参数正常R-R间期标准差正常R-R间期平均值标准差(SDNN)、正常R-R间期平均值标准差(SDANN)、Ln(p NN50)、正常R-R间期标准差平均值(SDNN index),频域参数总功率(TP)、低频功率(LF)、高频功率(HF)、归一化的低频功率(LF norm)、归一化的高频功率(HF norm)、LF/HF明显低于对照组(P0.05)。经抗抑郁治疗后抑郁症组HRV时域和频域参数显著上升(P0.05)。结论老年抑郁症患者HRV明显降低,说明机体自主神经系统对心率的调控作用受损,迷走神经兴奋性过低和(或)交感神经兴奋性过高。抗抑郁治疗对HRV有一定的改善作用。
[Abstract]:Objective to study the heart rate variability (HRV) of 24 h ambulatory electrocardiogram (ECG) in elderly patients with depression. Methods 31 elderly patients with depression were treated before and after antidepressant therapy with a three-channel physiological recorder. DCG waveforms were recorded in 28 patients with no psychological disorder. HRV time domain and frequency domain analysis were performed on the detected DCG. Results the normal R-R interval standard deviation of HRV time domain parameters was normal in 31 patients with depression. Standard deviation of interphase mean (. SDNN). The average standard deviation of normal R-R interval is SDANN / N50, and the average value of normal R-R interval standard deviation is SDNN indexer, the total power of frequency domain parameter is TPN). Low frequency power (LFN), high frequency power (HFN), normalized low frequency power (LF normals), normalized high frequency power (HF normals). LF/HF was significantly lower than that of control group (P 0.05). After antidepressant treatment, the parameters of HRV in time domain and frequency domain were significantly increased in depression group (P 0.05). Conclusion HRV in elderly patients with depression was significantly lower than that in control group (P < 0.05). The results suggest that the autonomic nervous system is impaired in regulating heart rate, the excitability of vagus nerve is too low and / or the excitability of sympathetic nerve is too high. Antidepressant therapy can improve HRV to some extent.
【作者单位】：许昌市中心医院神经内科三病区;
【分类号】：R749.4
【正文快照】： 抑郁症是老年病中常见的精神心理疾病。近年来,心理行为因素与冠心病发生发展的密切相关性已逐渐被临床医师所接受〔1〕。国外很多研究发现心血管疾病可以引起抑郁,而抑郁也可以诱发、加重心血管疾病,并对疾病的预后产生影响,认为抑郁是心血管疾病发生、发展及影响预后的独立

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