MECT对难治性抑郁症患者认知功能的影响

发布时间：2018-01-24 17:10

本文关键词： 难治性抑郁症改良电抽搐治疗认知功能　出处：《山东医药》2015年18期 　论文类型：期刊论文

【摘要】：目的探讨改良无抽搐电休克疗法(MECT)对难治性抑郁症(TRD)患者认知功能的影响及其安全性。方法对60例TRD患者给予MECT治疗,于治疗前及治疗8次后分别使用汉密尔顿抑郁量表(HAMD)评价抑郁程度,使用威斯康辛卡片分类测验、汉诺塔、言语流畅性、数学符号、数字广度、视觉再生、连线试验AB进行认知功能评定,治疗后采用副反应量表(TESS)评定不良反应。结果患者治疗后HAMD总分均明显下降,认知功能均明显改善,未出现严重不良反应。结论 MECT治疗难治性抑郁症可在改善抑郁症状的同时明显改善认知功能,且较为安全。
[Abstract]:Objective to investigate the effect and safety of modified electroconvulsive therapy (MECT) on cognitive function in patients with refractory depression. Methods 60 patients with TRD were treated with MECT. The depression was evaluated by Hamilton Depression scale (Hamd) before treatment and 8 times after treatment. Wisconsin Card sorting Test (Wisconsin), Hanotta, verbal fluency, mathematical symbols, and numerical span were used. Visual regeneration and line test AB were used to assess cognitive function and adverse reactions were assessed by side effects scale (TESS) after treatment. Results the total scores of HAMD were significantly decreased after treatment. Conclusion the treatment of refractory depression with MECT can improve the cognitive function as well as depressive symptoms, and is safe.
【作者单位】：广州市惠爱医院;
【基金】：国家自然科学基金面上项目(81371506)
【分类号】：R749.4
【正文快照】： 抑郁症患者存在认知功能损害,其短期记忆、长期记忆、决策过程、信息处理、反应时间及感觉运动的精确性都可能受到破坏。现有的抗抑郁剂对大多数抑郁症有良好效果,但仍有1/3的患者对抗抑郁剂无效,即难治性抑郁症(TRD)。目前对TRD的治疗主要采取抗抑郁药联合情绪稳定剂或抗精神

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