改良电休克治疗对双相障碍患者氧化应激水平的影响

发布时间：2018-02-01 00:16

本文关键词： 双相障碍氧化应激改良电休克治疗　出处：《上海交通大学学报(医学版)》2017年10期 　论文类型：期刊论文

【摘要】：目的·探讨改良电休克治疗(MECT)对双相障碍患者氧化应激水平的影响。方法·选取双相障碍患者43例(患者组)行MECT 6周,同时选取健康人群49例作为正常对照组。患者组在治疗前、治疗6周末用汉密尔顿抑郁量表-17项(HAMD-17),Young躁狂评定量表(YMRS)和临床总体印象量表-严重程度(CGI-S)评估患者的疗效。并对2组外周血进行超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)含量检测,进行组间比较及治疗前后比较。结果·MECT治疗前双相障碍患者与正常人群比较,血浆MDA、GSH-Px水平较高,而SOD水平较低,CAT活性则无差异;与抑郁状态相比,MDA水平在躁狂状态更高,且其水平与CGI-S评分呈正相关。MECT治疗后CGI-S评分显著下降,血浆MDA水平在躁狂状态和抑郁状态均较治疗前明显下降,而其余氧化应激指标无变化。结论·双相障碍患者存在氧化应激损伤,不同疾病状态损伤程度不同;MECT改善疾病症状同时使血浆MDA水平下降,而对抗氧化指标则没有影响。
[Abstract]:Objective: to investigate the effect of modified electroshock therapy on oxidative stress in patients with bipolar disorder. Methods: 43 patients with bipolar disorder (patient group) were treated with MECT for 6 weeks. At the same time, 49 healthy people were selected as normal control group. Before treatment, the patient group was treated with Hamilton Depression scale (Hamilton Depression scale) -17 items (HAMD-17) at the end of 6 weeks. The Young mania rating scale (YMRS) and the clinical general impression scale (CGI-S) were used to evaluate the efficacy of the two groups, and the peripheral blood of the two groups were treated with superoxide dismutase (SOD). The contents of catalase, glutathione peroxidase, malondialdehyde (MDA) and glutathione peroxidase (GSH-PxX) were measured. Results: before and after MECT treatment, the level of GSH-Px in plasma of patients with bipolar disorder was higher than that of normal subjects, but the level of SOD was lower. There was no difference in CAT activity. Compared with depression, the level of malondialdehyde (MDA) in manic state was higher, and its level was positively correlated with CGI-S score. CGI-S score decreased significantly after treatment. Plasma MDA levels were significantly lower in manic state and depression state than before treatment, but no change in other oxidative stress indexes. Conclusion: there is oxidative stress injury in bipolar disorder patients. The degree of injury was different in different disease states. MECT improves disease symptoms and decreases plasma MDA level, but has no effect on antioxidant index.
【作者单位】：上海交通大学医学院附属精神卫生中心;
【基金】：国家自然科学基金(81671326) “精准医学研究”国家重点专项(2016YFC0906402) 上海市精神卫生中心院级课题(2014-YJ-04,2015-YJGJ-03) 上海交通大学文理交叉认知专项基金项目(16JXRZ06) 上海市科学技术委员会科研计划项目(17411970000)~~
【分类号】：R749.4
【正文快照】： 双相障碍是一类以躁狂或轻躁狂发作和抑郁发作交替裂情感性精神障碍[2]。MECT作用机制尚未完全明了,有出现的精神障碍,影响患者的社会功能,患者自身感到痛研究认为MECT通过改善氧化和抗氧化的平衡来起到改善苦。有研究发现双相障碍与氧化应激损伤有关[1],氧化应精神症状的效果

【相似文献】