血清白细胞介素水平与儿童孤独症关系的研究

发布时间：2018-02-01 20:18

本文关键词： 血清白细胞介素儿童孤独症行为特征　出处：《中国妇幼保健》2014年05期 　论文类型：期刊论文

【摘要】：目的:探讨儿童孤独症与免疫系统的关系,为儿童孤独症病因学研究提供依据。方法:选取天津市4所启智学校及1所私立孤独症早教干预培训机构的孤独症儿童进行CABS、CARS、ABC量表的评定,运用酶联免疫吸附法检测血清IL-1β、IL-2R、IL-6、IL-8的水平,单因素分析血清白细胞介素与儿童孤独症的关系,相关分析孤独症儿童血清白细胞介素水平与行为特征的关系。结果:孤独症儿童血清IL-1β、IL-2R、IL-6、IL-8水平与正常参考值的差异有统计学意义(P0.01),且高于正常参考值。孤独症儿童血清IL-1β、IL-2R、IL-6、IL-8水平与ABC量表中躯体运动项目得分呈正相关(P0.05),与CARS量表得分相关性检验差异无统计学意义(P均0.05)。结论:孤独症儿童可能存在免疫系统损伤,血清白细胞介素水平可能与孤独症儿童的躯体运动障碍有关。
[Abstract]:Objective: to investigate the relationship between autism and immune system in children. Methods: 4 schools in Tianjin and 1 private autistic early education intervention training institution were selected to carry out cars. ABC scale was used to detect the level of IL-6 / IL-8 in serum IL-1 尾 -IL-2RU and IL-6 by Elisa, and the relationship between serum interleukin and autism in children was analyzed by univariate analysis. Results: the serum levels of IL-1 尾 and IL-2RN6 in autistic children were correlated with the behavioral characteristics of autistic children. The difference between IL-8 level and normal reference value was statistically significant (P 0.01) and higher than that of normal reference value (P < 0.05). The serum IL-1 尾 -IL-2RU IL-6 in autistic children was significantly higher than that of normal reference value (P < 0.05). The level of IL-8 was positively correlated with the score of somatic motor items in ABC scale (P 0.05). There was no significant difference between the correlation test and the score of CARS scale (P < 0.05). Conclusion: there may be immune system damage in autistic children. Serum interleukin level may be associated with somatic motor disorders in autistic children.
【作者单位】：天津医科大学公共卫生学院;
【基金】：国家自然科学基金资助项目〔81072313〕
【分类号】：R749.94
【正文快照】： 儿童孤独症(autism)又称自闭症,是由脑功能发育不良引起的,以社会交往、言语发育障碍、兴趣范围狭窄、行为刻板重复为基本特征的严重儿童发育障碍性疾病〔1〕。目前的流行病学调查研究〔2-3〕发现孤独症患儿自身存在免疫功能紊乱,如促炎细胞因子水平升高、自身抗体补体的异常

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