成人注意缺陷多动障碍不同亚型患者的工作记忆

发布时间：2018-02-12 03:52

本文关键词： 注意缺陷多动障碍亚型工作记忆 n-back任务临床研究　出处：《中国心理卫生杂志》2014年06期 　论文类型：期刊论文

【摘要】：目的:探讨成人注意缺陷多动障碍(ADHD)不同亚型患者的工作记忆特点,比较两种亚型患者的工作记忆受损程度。方法:选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的50例注意缺陷型(ADHD-I)、20例混合型(ADHD-C)成人患者及51例年龄、智商相匹配的正常对照(18~39岁)完成n-back(0、1、2)任务,比较三组被试的反应时(RT)、正确率和个体内反应时标准差(ISD)。结果:所有被试在完成n-back任务时,其RT和ISD均随工作记忆负荷增加而增大(P0.001),而正确率随工作记忆负荷增加而减小(P0.001),呈现等级变化规律。组间比较发现,ADHD-C患者完成n-back任务时反应时间长于正常对照[(535.9±115.9)ms vs.(470.1±66.5)ms,P0.01]和ADHD-I患者[(535.9±115.9)ms vs.(487.8±76.6)ms,P0.05],ADHD-C患者执行n-back任务时正确率低于正常对照[(88.3±10.1)%vs.(94.2±4.3)%,P0.01]和ADHD-I患者[(88.3±10.1)%vs.(93.2±6.6)%,P0.01],ADHD-C患者完成n-back任务时ISD大于正常对照[(166.7±41.9)vs.(147.3±33.1),P0.05];ADHD-I患者完成n-back任务时RT、正确率和ISD[(158.1±37.9)vs.(147.3±33.1)]与正常对照差异均无统计学意义(P0.05)。结论:成人ADHD不同亚型患者工作记忆受损程度可能不同,混合型患者的工作记忆受损程度可能较注意缺陷型更重。
[Abstract]:Objective: to investigate the working memory characteristics of different subtypes of ADHD in adults with attention deficit hyperactivity disorder (ADHD). Methods: 50 patients with attention deficit and 20 patients with ADHD-C and 51 patients with ADHD-C, who met the diagnostic criteria of DSM-IV4 of American Diagnostic and Statistical Manual for Mental Disorders, were selected to compare the degree of impairment of working memory between the two subtypes. The normal control (1839 years old) who matched intelligence quotient completed the task of n-back0 / 1) and compared the three groups' response time, correct rate and standard deviation of intra-individual reaction time (ISD). Results: all the subjects completed the n-back task. Both RT and ISD increased with the increase of working memory load, while the correct rate decreased with the increase of working memory load, showing the regularity of grade change. The results showed that the reaction time of ADHD-C patients to complete n-back task was longer than that of the normal control group [535.9 卤115.9 Ms]. The correct rate of n-back task in patients with vs.(470.1 卤66.5 Ms P0.01 and ADHD-I [535.9 卤115.9ms vs.(487.8 卤76.6msP05] was lower than that in normal controls [88.3 卤10.1vs.94.2 卤4.3 P0.01] and in ADHD-I patients [88.3 卤10.1vs.93.2 卤6.6P0.01] ISD in ADHD-C was higher than that in normal controls [166.7 卤41.9vs.147.3 卤33.1p0.05] and there was no significant difference between ADHD-C patients and normal controls. Conclusion: different subtypes of adult ADHD may have different degrees of impaired working memory. The degree of impairment of working memory in mixed patients may be more severe than that of attention deficit type.
【作者单位】：北京大学第六医院;北京大学精神卫生研究所;卫生部精神卫生学重点实验室(北京大学);
【基金】：国家自然科学基金(81371496,30970802) 973项目子课题(2014CB846104)
【分类号】：R749.94

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