首发精神分裂症患者的前联合白质完整性对认知功能的影响

发布时间：2018-02-21 06:45

本文关键词： 前联合精神分裂症认知障碍弥散张量纤维束成像　出处：《中国神经精神疾病杂志》2014年01期 　论文类型：期刊论文

【摘要】：目的研究首发精神分裂症患者前联合白质纤维完整性与精神分裂症的关系及其对认知功能的影响。方法对24例首发精神分裂症患者和29名正常对照者行弥散张量成像(diffusion tensor imaging,DTI)扫描,使用纤维束追踪的方法重建前联合纤维,并研究前联合纤维连接异常与认知功能间的关系。结果患者组前联合平均部分各向异性(fractional anisotropy,FA)值较对照组下降[(0.48±0.07)vs.(0.54±0.05),P=0.002],连线测验(trail making test,TMT)完成时间延长[TMT_A:(55.19±19.15)vs.(36.61±11.72),P0.001;TMT_B:(88.84±38.92)vs.(53.75±23.41),P0.001],逻辑记忆测试分数低于对照组[即刻逻辑记忆分数:(6.12±3.85)vs.(11.69±3.68),P0.001;延时逻辑记忆:(3.33±3.16)vs.(9.83±4.15),P0.001]。且患者组的FA值与TMT_A测验时间(r=-0.458,P=0.037)和TMT_B测验时间(r=-0.541,P=0.011)分别呈负相关,但在对照组未发现此相关性。结论本研究支持精神分裂症的脑功能连接异常假说,前联合白质纤维微结构受损可能是精神分裂症患者执行功能受损的原因之一,提示白质纤维完整性是精神分裂症的一个重要内表型。
[Abstract]:Objective to study the relationship between anterior leukofibrillary integrity and schizophrenia and its effect on cognitive function in patients with first-episode schizophrenia. Methods 24 patients with first-episode schizophrenia and 29 normal controls were treated with diffusive Zhang Liang. Imaging diffusion tensor imaging DTI scanning, Using the fiber bundle tracing method to reconstruct the pre-union fiber, Results compared with the control group, the mean partial anisotropic fractional anisotropy (FAA) decreased [0.48 卤0.07v s.0.54 卤0.05v. 0. 002], and the completion time of making test was prolonged [TMT_A:(55.19 卤19.15vs.36.61 卤11.72n P 0.001], the scores of logical memory test were 88.84 卤38.92nvs.53.75 卤23.41p0. 001 respectively. Compared with the control group, there was a negative correlation between the FA value of the patients and the TMT_A test time (r = -0.458p 0.037) and the TMT_B test time (r = -0.541g / P 0.011, respectively), which was significantly lower than that in the control group (n = 6.12 卤3.85 vs 11.69 卤3.68 / P 0.001; P 0.001; 3.33 卤3.16 vs 9.83 卤4.15 / P0.001 respectively), and was negatively correlated with the TMT_A test time (r = -0.458p 0.037) and the TMT_B test time (r = -0.541p = 0.011), respectively. Conclusion this study supports the hypothesis of abnormal connections of brain function in schizophrenic patients. The damage of white matter microstructures may be one of the causes of impaired executive function in schizophrenic patients. It is suggested that the integrity of white matter fibers is an important endophenotype of schizophrenia.
【作者单位】：四川大学华西医院心理卫生中心精神医学研究室人类疾病生物治疗国家重点实验室;广州市脑科医院;
【基金】：国家自然科学基金(编号:30971056、81130024、81171275) 科技部十二五支撑计划(编号:2011BAZ02530) 教育部博士点基金(编号:20110181110014、20110181120033)
【分类号】：R749.3

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