乌灵胶囊联合米氮平对更年期抑郁症患者神经内分泌的影响

发布时间：2018-02-24 10:23

本文关键词： 乌灵胶囊米氮平更年期抑郁症神经内分泌　出处：《中药药理与临床》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨乌灵胶囊联合米氮平治疗更年期抑郁症的疗效以及对患者神经内分泌的影响。方法:采用随机双盲对照法将我院195例更年期抑郁患者随机分为对照组和治疗组,对照组给予米氮平治疗,治疗组给予米氮平+乌灵胶囊治疗。治疗8周,观察并比较两组患者的汉密尔顿抑郁量表(HAMD)评分和改良Kupperman指数评分(KMI)、世界卫生组织生存质量测定量表简表(WHOQOL-BREF)评分、不良反应症状量表(TESS)。治疗前后测定并比较两组患者血清单胺类神经递质5-羟色胺(5-TH)、去甲肾上腺素(NE)、雌二醇(E2)、促卵泡激素(FSH)、促黄体生成素(LH)水平。结果:对照组和治疗组的有效率分别为80.61%和92.78%(P0.01)。治疗后2、4、6、8周与治疗前HADM评分比较2组均有明显降低,从治疗第2周末起,治疗组的HADM总分较对照组明显下降。治疗后两组间的KMI评分和WHOQOL-BREF评分比较均有显著性差异。治疗后两组患者的5-羟色胺(5-TH)和去甲肾上腺素(NE)较治疗前明显升高;治疗后两组患者的雌二醇(E2)、促卵泡激素(FSH)、促黄体生成素(LH)浓度较治疗前均有显著性差异。对照组的不良反应总数18例(18.37%),TESS值为(5.89±0.41)分;治疗组的不良反应总数8例(8.25%),TESS评分(3.14±0.28)分。治疗组的不良反应数及TESS明显低于对照组。结论:乌灵胶囊可提高米氮平治疗更年期抑郁症临床疗效,且不良反应少,依从性好,并能有效地调整患者的E2、FSH、LH水平,提高患者生存质量。
[Abstract]:Objective: to investigate the curative effect of Wuling capsule combined with miazapine on climacteric depression and its effect on neuroendocrine. Methods: 195 patients with climacteric depression in our hospital were randomly divided into control group and treatment group by randomized double-blind control. The control group was treated with mirtazapine, while the treatment group was treated with miazapine Wuling capsule for 8 weeks. To observe and compare the scores of Hamilton Depression scale (Hamd), modified Kupperman Index (Kupperman) and World Health Organization quality of Life scale (WHOQOL-BREFF) between the two groups. Before and after treatment, the serum levels of monoamine neurotransmitters 5-hydroxytryptamine 5-THN, norepinephrine, estradiol E _ 2, follicle stimulating hormone FSHN, luteinizing hormone (LH) were measured and compared between the two groups before and after treatment. The effective rates of the treatment group were 80.61% and 92.78, respectively. Compared with the HADM score before treatment, the HADM scores of the two groups were significantly lower than that of the control group. From the end of the second week of treatment, The total score of HADM in the treatment group was significantly lower than that in the control group. There were significant differences in KMI score and WHOQOL-BREF score between the two groups after treatment. After treatment, the concentrations of estradiol estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the two groups were significantly different from those before treatment. The total number of adverse reactions in the control group was 18.3710% (5.89 卤0.41). The number of adverse reactions and TESS in the treatment group were significantly lower than those in the control group. Conclusion: Wuling capsule can improve the clinical efficacy of metozapine in the treatment of menopausal depression, and the adverse reactions are less and the compliance is good. And can effectively adjust the level of E _ 2 FSH LH and improve the quality of life of patients.
【作者单位】：新乡医学院第二附属医院药学部;新乡医学院第二附属医院精神科;
【基金】：河南省卫生厅卫生政策研究课题(No.YWZY201348)
【分类号】：R749.4

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