轻度认知障碍患者体内微量元素Cu和Zn含量的Meta分析

发布时间：2018-02-26 13:19

本文关键词： 轻度认知障碍微量元素铜锌 Meta分析　出处：《现代预防医学》2017年06期 　论文类型：期刊论文

【摘要】：目的通过Meta分析方法研究轻度认知障碍患者体内微量元素Cu和Zn含量是否存在变化。方法采用Meta分析的方法,通过计算机检索Pub Med、EMbase、Web of Science、The Cochrane Library(2016年3期)、CNKI、VIP、CBM、Wan Fang Data数据库,检索时限为1990年1月-2016年5月,搜集与轻度认知障碍患者体内微量元素Cu和Zn含量相关的病例-对照研究。由2名研究者独立按照纳入排除标准、提取资料并进行文献质量评价后,采用Rev Man5.3进行数据分析。结果共纳入7篇病例-对照研究,总样本量达1 236人,文献质量总体较好。Meta分析显示,轻度认知障碍患者体内微量元素Cu含量处于中间值,其显著高于正常对照组[SMD=0.33,(95%CI=0.16,0.50),P=0.0002],低于阿尔茨海默症组[SMD=-0.25,95%CI(-0.49,-0.02),P=0.03];轻度认知障碍患者体内微量元素Zn含量低于正常对照组[SMD=-0.21,95%CI=(-0.61~-0.02),(P=0.03)],但可能高于AD组[SMD=0.29,95%CI=(-0.18,0.76),(P=0.22)],差异无统计学意义。结论认知功能下降的老年人体内存在微量元素Cu升高,Zn降低的趋势。
[Abstract]:Objective through the Meta analysis method in patients with mild cognitive impairment of trace elements Cu and Zn content of whether there are changes. Methods using Meta analysis method, the retrieval of Pub Med, EMbase Web of Science by computer, The, Cochrane, Library (2016 3), CNKI, VIP, CBM, Wan Fang Data database, retrieval time for January 1990 -2016 in May, and collected a case-control study of mild cognitive impairment in patients with Cu and Zn related to the content of trace elements. By 2 researchers independently according to the inclusion and exclusion criteria, literature quality evaluation and data extraction, using Rev Man5.3 for data analysis. Results a total of 7 case-control study samples up to 1236 people, the quality is generally good in.Meta analysis showed that patients with mild cognitive impairment in the trace element content of Cu in the middle of the range, which was significantly higher than normal control group (95%CI=0.16,0.50), [SMD= 0.33, P= 0.0002], [SMD=-0.25,95%CI is lower than that of Alzheimer's disease group (-0.49, -0.02, P=0.03]); in patients with mild cognitive impairment in the trace element content of Zn lower than the normal control group (-0.61~-0.02), [SMD=-0.21,95%CI= (P=0.03)], but may be higher than that of AD group (-0.18,0.76), [SMD=0.29,95%CI= (P=0.22)], the difference was not statistically significant. Conclusion elderly cognitive function decline in the presence of trace elements of Cu increased, Zn decreased.

【作者单位】：吉林大学护理学院;吉林大学基础医学院药学院;
【基金】：国家自然科学基金(81570762)
【分类号】：R749.1

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