DRD2基因TaqIA多态性与同伴侵害对青少年早期抑郁的交互作用

发布时间：2018-02-26 17:04

本文关键词： DRD基因TaqIA多态性同伴侵害抑郁性别差异　出处：《心理学报》2017年01期 　论文类型：期刊论文

【摘要】：本研究运用问卷法与DNA分型技术,对1063名青少年(初次测评年龄为12.32±0.47岁,50.3%女生)进行间隔2年的追踪调查,考察DRD2基因TaqIA多态性与同伴身体侵害和关系侵害对青少年早期抑郁的交互作用及其性别差异。结果发现,TaqIA多态性与身体侵害、关系侵害均对男青少年抑郁存在显著的交互作用。在携带A2A2基因型的男生中,身体侵害和关系侵害可以显著正向预测其抑郁水平,而在携带A1等位基因的男生中,同伴侵害对抑郁无预测作用。此外,TaqIA多态性与身体侵害、关系侵害对女生抑郁均无显著交互作用。研究结果提示,同伴侵害是一种重要的候选环境指标,与TaqIA多态性交互影响青少年早期抑郁,并且性别在这一基因×环境交互作用中起到重要的调节效应。
[Abstract]:In this study, 1 063 adolescents (12. 32 卤0. 47 years old and 50. 3% girls) were investigated by questionnaire and DNA typing technique. To investigate the interaction between DRD2 gene TaqIA polymorphism and peer physical and relational aggression and their gender differences in adolescents with early depression, the results showed that TaqIA polymorphism and physical invasion. In boys with A2A2 genotype, physical aggression and relationship aggression could significantly positively predict their depression level, while in boys with A1 allele, there was significant interaction between them. There was no predictive effect of peer aggression on depression. In addition, there was no significant interaction between TaqIA polymorphism and physical aggression, and there was no significant interaction between association aggression and depression in girls. The results suggest that peer aggression is an important candidate environmental indicator. Interaction with TaqIA polymorphism affects early depression in adolescents and sex plays an important regulatory role in the interaction of this gene 脳 environment.
【作者单位】：山东师范大学心理学院;
【基金】：国家自然科学基金项目(31271105;31671156) 高等学校博士学科点专项科研基金项目(博导类20133704110001)
【分类号】：R749.4

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