认知障碍患者theta节律脑功能网络连接异常

发布时间：2018-02-28 10:58

本文关键词： 脑电相位同步脑功能网络 Theta频带　出处：《生物物理学报》2014年05期 　论文类型：期刊论文

【摘要】：为了深入观察不同认知功能老年人的大脑功能连接特性,选取了20名老年人参与京剧体验任务,并记录了他们在听京剧前后闭眼静息状态下的脑电信号。根据被试简易精神状态量表得分将其分为高分组与低分组,通过分别计算不同脑电频带下的相位同步指数,构建了两组被试的大脑功能网络;然后,进一步计算了网络连接参数聚类系数和特征路径长度,并从不同角度分析了不同被试的大脑功能连接特性。结果发现:在theta频带下,低分组老年人的全局相位同步指数低于高分组;在京剧体验之后,高分组老年人theta频带的全局相位同步指数有显著提高,而低分组在各频段都没发现京剧效应;在固定阈值的前提下,低分组老年人在较大阈值范围内的聚类系数低于高分组,而特征路径长度高于高分组,表现出小世界特性相对缺失;进一步地,在保证不同被试脑网络边数相同的条件下(即采用相同的度),对两组被试的脑网络参数进行了统计分析,未发现组间差异。综上,较低认知能力的老年人表现出更少的脑网络连接边数。该研究表明,认知障碍老年人脑功能网络相对于正常人有所破损,京剧可以增强老年人的大脑功能连接特性。
[Abstract]:In order to observe the characteristics of brain function connection in the elderly with different cognitive functions, 20 elderly people were selected to participate in the Beijing Opera experience task. The EEG signals were recorded before and after hearing Beijing Opera. According to the scores of the simple mental state scale, they were divided into high score group and low group. The phase synchronization index of different EEG frequency bands was calculated respectively. The brain functional network of two groups of subjects was constructed, and then the clustering coefficient and characteristic path length of the network connection parameters were further calculated, and the characteristics of brain functional connection were analyzed from different angles. The results showed that: under the theta band, After the experience of Beijing Opera, the global phase synchronization index of theta frequency band in the high score group increased significantly, but no Peking Opera effect was found in the low group. On the premise of fixed threshold, the clustering coefficient of the lower group is lower than that of the high score group in the larger threshold range, while the length of the characteristic path is higher than that of the high score group, which shows that the small world characteristic is relatively missing. Under the condition that the number of brain network edges of different subjects is the same (that is, using the same degree), the network parameters of the two groups are statistically analyzed, and no differences between the two groups are found. Older people with lower cognitive ability showed fewer brain network connections. The study showed that cognitive impairment in the elderly was more damaged than that in the normal population, and Peking Opera could enhance the brain functional connectivity in the elderly.
【作者单位】：上海大学通信与信息工程学院;
【基金】：上海市教育委员会自然创新重点项目(12ZZ099) 国家自然科学基金项目(61171032) 首都医科大学北京宣武医院-北京市重点实验室-脑功能疾病调控治疗实验室开放研究课题(2013NBTK02)~~
【分类号】：R749.16

【共引文献】