不同时辰轻度认知功能障碍患者动态脑电图定量分析的警示性改变

发布时间：2018-03-02 22:08

本文选题：轻度认知功能障碍　切入点：时辰　出处：《山东中医药大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：了解不同时辰轻度认知功能障碍患者脑电图的变化，提炼出客观可量化的异常指标，探索轻度认知功能障碍患者脑电图及MMSE量表的相关性，为日后早期诊断预防认知功能障碍提供依据。方法：以我院收治的轻度认知功能障碍老年患者30例为研究对象，并以社会招募正常健康老年人30例为对照，，分别进行MMSE测试和24小时脑电图监测。选取无干扰定标脑电图以及子时、寅时、辰时、午时和申时、酉时六个不同时辰的脑电图，比较两组不同时辰脑电图各波功率并对轻度认知功能障碍患者MMSE各项评分与脑电图相关性分析。结果：1.无干扰定标脑电图病例组和对照组的双侧顶枕α功率及大脑各位点的慢波功率差别有统计学意义（p㩳0.05）。2.寅时病例组与对照组α功率之间的比较有统计学意义（p㩳0.05），慢波功率比较无统计学意义（p＞0.05）。3.病例组及对照组在睡眠2期纺锤波的时限、频率及密度差别有统计学意义（p㩳0.05）。4.辰时、午时、申时及酉时病例组和对照组的双侧顶枕α功率差别有统计学意义（p㩳0.05）；大脑各位点的慢波功率差别有统计学意义（p㩳0.05）。5.病例组辰时、午时、申时及酉时间α功率差别无统计学意义（p＞0.05）。6.病例组的MMSE中时间定向力、记忆力与脑电图的慢波或α波存在相关性（p㩳0.05）。结论：1.不同时辰的α波功率、θ和δ波功率及子时睡眠2期纺锤波的密度、时限及频率可以作为诊断轻度认知功能障碍的参考指标；2.寅时α波功率下降可以提示早期认知功能减退；3.清醒期辰时、午时、申时及酉时的不同时辰间轻度认知功能障碍的脑电图差异参考意义不大；4.轻度认知功能障碍的MMSE时间定向力及记忆力与脑电图α波、θ和δ波的绝对功率有相关性。
[Abstract]:Objective: to investigate the changes of electroencephalogram (EEG) in patients with mild cognitive impairment (MCI) at different times, to extract the objective and quantifiable abnormal indexes, and to explore the correlation between EEG and MMSE scale in patients with mild cognitive impairment. Methods: 30 elderly patients with mild cognitive impairment were selected as the study objects, and 30 normal and healthy elderly people were recruited as control. MMSE test and 24 hour EEG monitoring were carried out respectively. The EEG of six different times were selected, including non-interference calibrated EEG and sub-time, Yin, Chen, noon and Shen, and unitary time. The correlation between MMSE scores and EEG in patients with mild cognitive impairment was analyzed. Results: 1. A power of bilateral parietal occipital 伪 and large occipital power in non-interference calibrated EEG group and control group were compared. The difference of slow wave power in each point of the brain is statistically significant. The comparison of 伪 power between the case group and the control group was statistically significant. There was no significant difference in slow wave power between the two groups (P > 0.05). The time limit, frequency and density of spindles in the case group and the control group were significantly different in sleep phase 2. The difference of bilateral parietal occipital 伪 power between the case group and the control group was statistically significant. The difference of slow wave power in each point of the brain is statistically significant. There was no significant difference in 伪 power between the two groups (P > 0.05). Time orientation, memory and slow or 伪 wave of electroencephalogram were correlated with the time orientation in the case group (P > 0.05), and the correlation between the memory and the slow or 伪 wave of EEG was also found in the case group (P > 0.05). Conclusion: 1. 伪 wave power, 胃 and 未 wave power at different times, and density of spindles at sub-sleep stage 2, The time limit and frequency can be used as a reference index for the diagnosis of mild cognitive dysfunction. The decrease of alpha wave power can indicate early cognitive dysfunction. (4) the MMSE time orientation and memory of mild cognitive impairment were correlated with the absolute power of 伪 wave, 胃 wave and 未 wave of EEG.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16

【参考文献】