MTHFR基因单核苷酸多态性与中国南方汉族阿尔茨海默病的相关性分析

发布时间：2018-03-09 22:41

本文选题：亚甲基四氢叶酸还原酶　切入点：单核苷酸多态性　出处：《实用医学杂志》2014年11期 　论文类型：期刊论文

【摘要】：目的:探讨中国南方汉族人群中阿尔茨海默病(AD)的发生与5,10-亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因677位点单核苷酸多态性(677C→T突变)的关系。方法 :利用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术,检测45例AD患者和48例健康老年人的MTHFR基因的单核苷酸多态性,并加以对照分析。结果:AD患者MTHFR基因677位点的各基因型分布与对照组间无显著差异(P0.05)。AD组和对照组间C、T基因频率分布差异也无统计学意义(P0.05),但AD组中,T基因的频率略高于对照组。结论:本研究中MTHFR基因677位点单核苷酸多态性(677C→T突变)不是AD发病的致病因素,但可能对AD有一定影响。
[Abstract]:Objective: to investigate the occurrence of Alzheimer's disease (ADD) and the single nucleotide polymorphism of 5methylenetetramethylenetetrahydrofolate reductase (MTHFR) gene 677 in the Han population in southern China. 鈫扢ethods: polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect the single nucleotide polymorphisms of MTHFR gene in 45 AD patients and 48 healthy elderly people. Results there was no significant difference between the genotype distribution of MTHFR gene 677 locus and that of the control group. There was no significant difference in the frequency distribution of CfT gene between AD group and control group, but there was no significant difference between AD group and control group, but the frequency of T gene in AD group was not significantly different from that in AD group. Conclusion: in this study, the single nucleotide polymorphism of MTHFR gene 677 was 677C. 鈫扵 mutation is not the pathogenic factor of AD, but it may have some effect on AD.
【作者单位】：长沙医学院人体解剖与组织胚胎学省重点建设学科;长沙医学院附属岳化医院神经内科;湖南省岳阳市中医医院;长沙医学院临床学院;
【基金】：湖南省教育厅科研项目(编号:11C0131)
【分类号】：R749.16

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