轻度认知障碍工作记忆中theta振荡的特征研究

发布时间：2018-03-14 13:01

本文选题：轻度认知障碍　切入点：工作记忆　出处：《天津医药》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨轻度认知障碍(MCI)患者工作记忆(WM)障碍theta振荡的特征模式。方法选取2016年1月—11月就诊于天津医科大学总医院的MCI患者(MCI组)和健康体检者(对照组)各15例。比较2组受试者执行视觉工作记忆任务的行为学差异。同步采集34通道脑电信号,应用短时傅里叶变换进行多通道脑电信号的能量空间分布、时频分布和频谱相干分析。结果与对照组相比,在工作记忆行为学方面,MCI组的反应时间明显延长,正确率明显下降,差异均有统计学意义(P0.01)。脑电信号分析显示2组在额中线Fz通道的theta振荡能量最大,但MCI组额区theta振荡能量密度较对照组明显减低(P0.01),额区内部及额-后部脑区之间theta振荡的同步性明显下降(P0.05)。结论 MCI患者额区theta振荡的缺失可能是其WM障碍的重要机制之一。
[Abstract]:Objective to explore the characteristic mode of theta oscillation of working memory disorder in patients with mild cognitive impairment. Methods the patients with MCI from January 2016 to November were selected from Tianjin Medical University General Hospital) and healthy persons (control group). 15 cases. The behavioral differences of two groups of subjects performing visual working memory tasks were compared. The 34-channel EEG signals were collected synchronously. The energy spatial distribution, time-frequency distribution and spectral coherence of multichannel EEG signals were analyzed by using short-time Fourier transform. Results compared with the control group, the reaction time and the correct rate of MCI group were significantly prolonged and the correct rate was significantly decreased compared with the control group. The difference was statistically significant (P 0.01). EEG analysis showed that the theta oscillation energy of FZ channel in the middle frontal line of the two groups was the largest. However, the energy density of theta oscillation in frontal area of MCI group was significantly lower than that of control group, and the synchronism of theta oscillation in frontal region and frontoposterior brain region was significantly decreased. Conclusion the absence of theta oscillation in frontal area of MCI patients may be one of the important mechanisms of its WM disturbance.
【作者单位】：天津医科大学总医院神经内科;天津医科大学生物医学工程与技术学院;
【基金】：天津市应用基础与前沿技术研究计划项目(14JCZDJC35400) 2016年度天津市“131”创新型人才团队培养工程
【分类号】：R749.1

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