文拉法辛对卒中后抑郁患者认知功能改善的影响

发布时间：2018-03-17 19:24

本文选题：文拉法辛　切入点：卒中　出处：《重庆医学》2014年22期 　论文类型：期刊论文

【摘要】：目的观察文拉法辛对卒中后抑郁患者认知功能障碍的改善情况及其安全性。方法选取本院神经内科收治的卒中后抑郁并认知功能障碍的患者72例,按照随机数字表法将其分为观察组和对照组各36例。对照组按照急性脑卒中常规治疗方案进行治疗,观察组在对照组治疗方案的基础上,加用文拉法辛片口服。采用简易智能量表(MMSE)、蒙特利尔认知评估量表(MoCA)、日常生活活动能力量表(ADL)在治疗前、治疗第4周和治疗第12周对两组患者进行评估。用统计方法对比分析两组患者的量表评估结果。结果治疗4周后,观察组MoCA评分为(18.52±4.37)分,MMSE评分为(20.61±4.85)分,均显著高于治疗前,而ADL评分为(35.27±4.75)分,显著低于治疗前(P0.05);治疗12周后,观察组MoCA评分为(20.14±5.26)分,MMSE评分为(22.46±4.59)分,均显著高于对照组,而ADL评分为(29.85±5.07)分,显著低于对照组(P0.05);观察组有2例出现轻度胃肠道不适,2例出现轻度头晕,未发生严重的不良反应事件。结论文拉法辛能够显著改善卒中后抑郁患者的认知功能,提高患者的自理能力,同时具有良好的安全性。
[Abstract]:Objective To observe the effect of venlafaxine on post-stroke depression patients with cognitive dysfunction to improve the situation and its safety. Methods the stroke admitted in the Department of Neurology in our hospital after the depression and cognitive impairment in patients with 72 cases, were randomly divided into observation group and control group with 36 cases in each group. The control group were treated with routine treatment of acute stroke scheme, the observation group in the control group based on the treatment, combined with venlafaxine tablets. The simple Intelligence Scale (MMSE), Montreal cognitive assessment scale (MoCA), activities of daily living scale (ADL) before treatment, treatment for fourth weeks and twelfth weeks of treatment, two groups of patients were evaluated. The analysis of two groups of patients were evaluated by statistical method. The comparison results after 4 weeks of treatment, the observation group MoCA score was (18.52 + 4.37), MMSE score (20.61 + 4.85), were significantly higher than that before treatment, and ADL score For (35.27 + 4.75), was significantly lower than that before treatment (P0.05); after 12 weeks of treatment, the observation group MoCA score was (20.14 + 5.26), MMSE score (22.46 + 4.59), were significantly higher than control group, while the ADL score was (29.85 + 5.07)%, significantly lower than the control group the observation group (P0.05); 2 patients had mild gastrointestinal discomfort, 2 cases had mild dizziness, no serious adverse events. Conclusion venlafaxine can cognitive function in patients with post stroke depression improved significantly, improve the self-care ability of patients, with good safety.

【作者单位】：河南省郑州市第一人民医院神经内科;
【分类号】：R749.1

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