5-HTTLPR与应激的交互效应对抑郁症状预测作用的纵向研究

发布时间：2018-03-19 20:02

本文选题：5-HTTLPR　切入点：抑郁症状　出处：《中南大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的(1)检验5-羟色胺转运体基因启动子区域连锁多态性(5-HTTLPR)对青少年抑郁症状的影响；(2)检验5-HTTLPR与应激性生活事件的交互效应对抑郁症状的预测作用。方法随机抽取湖南省长沙市某所高中的252名高一年级学生,并进行为期2年共9次的追踪研究。初次测评时,分别用流调中心用抑郁量表(Center for Epidemiological Studies Depression Scale, CES-D)和青少年生活事件问卷(Adolescent Life Events Questionnaire, ALEQ)评估被试的抑郁症状和生活事件,并抽取5mL静脉血以提取DNA和鉴定5-HTTLPR基因型。初测后的2年中,每隔3个月对所有被试的抑郁症状和生活事件进行追踪评估,共8次追踪。运用多层线性模型(Hierarchical Linear Model, HLM)对收集的数据进行统计分析。结果多层线性模型分析显示：(1)生活事件对男性和女性的抑郁症状均有显著预测作用(男性：β=0.14,p0.0001；女性：β=0.13,p0.0001);(2)5-HTTLPR对男性和女性的抑郁症状的预测作用均无主效应(男性：β=0.21,p0.05；女性：β=1.16,p0.05)；(3)女性样本中,5-HTTLPR与生活事件交互作用显著(β=0.08,p0.0001),携带S等位基因型的个体在应激性生活事件后会表现出更高的抑郁症状；男性样本中,无显著交互作用(β=-0.03,p0.05)。结论5-HTTLPR对青少年抑郁症状无预测作用；5-HTTLPR与应激的交互作用能够预测女性青少年的抑郁症状,而对男性青少年抑郁症状没有预测作用。
[Abstract]:Objective to test the effect of 5-HTTLPRs on depression symptoms in adolescents by using 5-HTTLPR) to test the predictive effect of 5-HTTLPR and stress life events on depression symptoms. Methods A total of 252 freshmen from a high school in Changsha, Hunan Province, were randomly selected and followed up for 2 years and 9 times. Depression symptoms and life events were assessed with the Center for Epidemiological Studies Depression scale (CES-D) and Adolescent Life Events questionnaire (ALEQs), and 5 mL venous blood was extracted to extract DNA and identify 5-HTTLPR genotypes. The depressive symptoms and life events of all subjects were tracked and evaluated every 3 months, and the collected data were statistically analyzed by using the hierarchical Linear Model (HLMModel). Results the multilevel linear model analysis showed that life events had significant predictive effects on both male and female depressive symptoms (male: 尾 = 0.14, p 0.0001; female: 尾 = 0.13, p 0.0001). There was no significant predictive effect of 5-HTTLPR on depressive symptoms in both males and females (male: 尾 0.21, p0.05; female: 尾: 尾 0.21, p0.05; male: 尾 0.21, p0.05; female: 尾: 尾 0.21, p0.0001; male: 尾 0.21, p0.05; male: 尾 0.21, p0.0001; Sex: in female samples, the interaction between 5-HTTLPR and life events was significant (尾 0.08% p0.0001). Individuals with S allele showed higher depressive symptoms after the stress sexual events. There was no significant interaction in male samples (尾 -0.03 P 0.05). Conclusion there is no predictive effect of 5-HTTLPR on depression symptoms in adolescents. The interaction between 5-HTTLPR and stress can predict depression symptoms in female adolescents, but not in male adolescents.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.4

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