强制戒断时间对海洛因成瘾者大脑局部一致性影响的静息态功能MRI

发布时间：2018-03-20 22:22

本文选题：海洛因　切入点：局部一致性　出处：《中国医学影像技术》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨静息态下强制戒断时间对海洛因成瘾者大脑局部一致性(ReHo)的影响。方法纳入20例强制戒断6个月(戒断6个月组)、16例戒断11个月(戒断11个月组)的海洛因成瘾者和30名(正常对照组)人口学数据相匹配的健康受试者,采集其静息态fMRI数据,计算并比较3组间ReHo值,利用Pearson相关分析法分析差异脑区ReHo值与戒断时间的关系。结果 3组间ReHo值有统计学差异的脑区为左侧海马旁回、尾状核、岛叶、扣带回、中央后回及右侧眶额回。戒断11个月组ReHo值低于戒断6个月组的脑区为左侧海马旁回、尾状核、岛叶、扣带回及中央后回,右侧眶额回ReHo值高于戒断6个月组及正常组。左侧海马旁回(r=0.53,P=0.000 8)、尾状核(r=0.54,P=0.000 6)、岛叶(r=0.62,P0.000 1)、扣带回(r=0.47,P=0.003 5)及中央后回(r=0.35,P=0.034 8)的ReHo值分别与戒断时间呈负相关,右侧眶额回(r=0.66,P0.000 1)ReHo值与戒断时间呈正相关。结论海洛因成瘾者多数受损脑区(渴求、抑制性控制及学习记忆等)经长期戒断后功能趋于恢复正常,而动机/驱动脑区(眶额回)活动异常增高可能是戒断后复吸的原因之一。
[Abstract]:Objective to investigate the effect of compulsory withdrawal time under resting state on local consistency of brain in heroin addicts (ReHo.Methods Twenty patients with 6 months of compulsory withdrawal were enrolled in the study group, 16 patients with 11 months of withdrawal (11 months of withdrawal) were included in the sea. Loren addicts and 30 healthy subjects matched by demographic data (normal control group), The resting fMRI data were collected, and the ReHo values were calculated and compared among the three groups. Pearson correlation analysis was used to analyze the relationship between the ReHo values in the different brain regions and the withdrawal time. Results the regions with significant differences in ReHo values among the three groups were the left pariprahippocampal gyrus and caudate nucleus. The ReHo values of 11 months abstinence group were lower than those of 6 months abstinence group: left parahippocampal gyrus, caudate nucleus, island lobe, cingulate gyrus and postcentral gyrus. The ReHo value of right orbital frontal gyrus was higher than that of abstinent 6 months group and normal group. The ReHo values of left perihippocampal gyrus were negatively correlated with the abstinence time. There was a positive correlation between the value of right orbitofrontal gyrus 0.06 P 0.000 1L ReHo and withdrawal time. Conclusion the function of most damaged brain areas (craving, inhibitory control, learning and memory) in heroin addicts tended to return to normal after a long period of abstinence. The abnormal increase of motor / drive brain area (orbital frontal gyrus) may be one of the causes of relapse after withdrawal.
【作者单位】：第四军医大学唐都医院放射诊断科;
【基金】：国家自然科学基金面上项目(81671661、81371532)
【分类号】：R749.64

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