帕罗西汀片和氯米帕明片治疗抑郁症的临床研究

发布时间：2018-03-21 01:52

本文选题：帕罗西汀片　切入点：氯米帕明片　出处：《中国临床药理学杂志》2017年15期 　论文类型：期刊论文

【摘要】：目的比较帕罗西汀片和氯米帕明片治疗抑郁症的临床疗效及安全性。方法将120名抑郁症患者随机分为对照组40例、试验A组40例和试验B组40例。对照组予以安慰剂每次45 mg,tid,口服;试验A组予以氯米帕明每次25mg,tid,口服;试验B组予以帕罗西汀每次20 mg,qd,口服。3组患者均治疗10周。比较2组患者的临床疗效、汉密尔顿抑郁量表(HAMD)评分,以及药物不良反应的发生情况。结果试验A组、试验B组和对照组治疗4周后的HAMD评分分别为(18.64±1.06),(17.12±1.54)和(22.45±1.24)分,治疗10周后的HAMD评分分别为(13.20±0.99),(12.81±0.98)和(21.12±1.05)分,试验A、B组与对照组比较差异均有统计学意义(均P0.05)。治疗后,试验A组、试验B组和对照组的总有效率分别为90.00%(36/40例),85.00%(34/40例)和30.00%(12/40例),试验A、B组与对照组比较差异均有统计学意义(均P0.05)。试验A组的药物不良反应主要有恶心、体重减轻、头昏和焦虑,试验B组常见的药物不良反应是恶心、体重减轻和头昏,试验A组和试验B组的药物不良反应发生率分别为30.00%和10.00%,差异有统计学意义(P0.05)。结论帕罗西汀片和氯米帕明片治疗抑郁症的临床疗效相当,但前者的药物不良反应发生率明显低于后者。
[Abstract]:Objective to compare the efficacy and safety of paroxetine tablets and clomipramine tablets in the treatment of depression. Group A (n = 40) and group B (n = 40) were treated with placebo 45 mg / d, group A with clomipramine (25 mg / d) and group A with clomipramine (25 mg / d). Group B was treated with paroxetine 20 mg / time for 10 weeks. The clinical efficacy, Hamilton Depression scale (Hamilton Depression scale) score, and adverse drug reactions were compared between the two groups. The HAMD scores of group B and control group were 18.64 卤1.06 卤17.12 卤1.54 and 22.45 卤1.24 respectively after 4 weeks of treatment. The scores of HAMD after 10 weeks of treatment were 13.20 卤0.99 卤0.98) and 21.12 卤1.05, respectively. There was significant difference between group A and control group (P 0.05). The total effective rates of group B and control group were 90.0036 / 40 and 30.0012 / 40, respectively. There were significant differences between group A and control (all P 0.05). The adverse drug reactions in group A were mainly nausea, weight loss, dizziness and anxiety. The common adverse drug reactions in group B were nausea, weight loss and dizziness. The incidence of adverse drug reactions in group A and group B were 30.00% and 10.00, respectively. The difference was statistically significant (P 0.05). Conclusion Paroxetine and clomipramine are effective in the treatment of depression. However, the incidence of adverse drug reactions in the former was significantly lower than that in the latter.
【作者单位】：四川省人民医院心身医学中心;
【基金】：西部精神医学协会科研基金资助项目(WCPAFUND_201502)
【分类号】：R749.4

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