老年轻度认知障碍患者Stroop效应的诊断界值

发布时间：2018-03-25 01:15

本文选题：轻度认知障碍　切入点：Stroop效应　出处：《中国老年学杂志》2017年15期

【摘要】：目的探索老年轻度认知障碍(MCI)患者客观量化的临床筛检指标,简化测评手段,减少主观评判误差。方法采用1∶1病例对照研究方法确定MCI组和对照组各46例,应用Stroop色字干扰测验评定其认知功能缺损程度。结果 MCI与对照组Stroop效应耗时A、B、C、(C-B)/A和正确数A、B、C、(B-C)/A均有统计学差异(P0.05或P0.01)。Stroop效应耗时A、B、(C-B)/A与Mo CA总分、视空间、注意力、记忆力(耗时A除外)、抽象思维存在相关性,耗时C与Mo CA总分、注意力、记忆力存在相关性(P0.05或P0.01);正确数A与注意力存在相关性,正确数B与Mo CA总分、注意力、记忆力、命名存在相关性,正确数C与Mo CA总分、注意力存在相关性,正确数(B-C)/A与Mo CA总分、视空间、注意力、记忆力存在相关性(P0.05或P0.01)。Stroop效应受试者工作特征(ROC)曲线分析,耗时增加率(C-B)/A38.5%时筛检MCI的灵敏度71.7%、特异度71.6%、约登指数43.3%;正确数递减率(B-C)/A4.2%时,灵敏度73.9%、特异度78.3%、约登指数52.2%;耗时增加率38.5%或正确数递减率4.2%并联筛检MCI的灵敏度91.3%、特异度93.5%、约登指数84.8%。结论 MCI患者存在多重领域认知功能损害,主观测评难度较大,Stroop效应诊断MCI具有较好的灵敏度和特异度,测验简单快捷,较为适合作为老年人群体检中筛查MCI的检测工具。
[Abstract]:Objective to explore the objective and quantitative clinical screening indexes of elderly patients with mild cognitive impairment (MCI), simplify the evaluation method and reduce the subjective judgment error. Methods the 1:1 case-control study was used to determine 46 cases in MCI group and 46 cases in control group. Results there were significant differences in the duration of Stroop effect between MCI and the control group (P 0.05) or P0.01).Stroop effect (P 0.05) or P0.01).Stroop effect (P 0.05), visual space, attention, total CA, visual space, attention, and so on, and the results showed that there were significant differences in the duration of Stroop effect between MCI and the control group (P 0.05), and the effect of P0.01).Stroop on C-B / C / A / A ratio A / A was significantly different from that of the control group (P < 0.05). Memory (except for time-consuming A, there was correlation between abstract thinking, time consuming C and Mo CA total score, attention, memory correlation P 0.05 or P 0.01), correct number A was correlated with attention, correct number B and Mo CA total score, attention, memory, There was correlation between naming, correct number C and total score of Mo CA, total score of attention, total score of B-CU / A and Mo CA, correlation of visual space, attention and memory (P0.05 or P0.01).Stroop effect) curve analysis. The sensitivity of screening MCI was 71.7%, the specificity was 71.6, the Yorden index was 43.3%, and the correct decline rate was 4.2% when C-BN / A38.5%. Sensitivity 73.9%, specificity 78.3%, Yorden index 52.2%, time consuming increase rate 38.5% or correct number decline rate 4.2%, sensitivity 91.3%, specificity 93.5%, and Yorden index 84.8. Conclusion there are multiple domain cognitive impairment in patients with MCI, and the sensitivity is 91.3%, the specificity is 93.5%, and the Jorden index is 84.8%, and the sensitivity is 91.3%, the specificity is 93.5%, and the Yorden index is 84.8%. The subjective evaluation is more difficult than the Stroop effect in the diagnosis of MCI. It has good sensitivity and specificity, and the test is simple and quick. It is suitable for the detection of MCI in the physical examination of the elderly population.
【作者单位】：嘉兴学院医学院;
【基金】：2015级国家级大学生创新项目(No.201510354021) 嘉兴市科技计划项目(No.2012AY1075-1)
【分类号】：R749.1

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