利培酮短期治疗的男性精神分裂症患者催乳素水平对胰岛素敏感性的影响

发布时间：2018-03-30 10:58

  本文选题：利培酮　切入点：精神分裂症　出处：《中国新药与临床杂志》2014年03期

【摘要】：目的初步探讨利培酮短期治疗的男性精神分裂症患者催乳素水平对胰岛素敏感性的影响。方法将符合入组标准的51例利培酮治疗2~6周的住院精神分裂症患者依据催乳素水平分为A组(催乳素≥800 mIU·L~(-1))27例和B组(催乳素800 mIU·L~(-1))24例,比较两组的胰岛素敏感性指标和体重指数(BMI);依据BMI分为正常体重组(BMI 18.5~23.9 kg·m~(-2))29例和超重组(BMI≥24 kg·m~(-2))22例,比较两组的血清催乳素和胰岛素敏感性指标。结果 A、B两组空腹胰岛素(FINS)、稳态模型评估胰岛素抵抗指数(HONA-IR)、定量胰岛素敏感性检测指数(QUICKI)均无显著差异(P0.05)。正常体重组与超重组的催乳素水平无显著差异(P0.05);超重组FINS、HOMA-IR高于正常体重组(P0.01),超重组QUICKI低于正常体重组(P0.01)。结论利培酮短期治疗后的男性精神分裂症患者中体重超重者胰岛素敏感性降低,而催乳素水平不影响患者的体重及胰岛素敏感性。
[Abstract]:Objective to investigate the effect of prolactin level on insulin sensitivity in male schizophrenic patients treated with risperidone for short term. Methods 51 patients with schizophrenia treated with risperidone for 2 to 6 weeks were treated with risperidone for 2 weeks. Prolactin levels were divided into two groups: group A (n = 27) and group B (n = 24). The insulin sensitivity index and body mass index (BMI) were compared between the two groups, which were divided into two groups according to BMI: normal body mass index 18.53.9 kg / kg mAM-2n = 29, and hyperrecombination BMI 鈮，

本文编号：1685624