阿尔茨海默病患者嗅觉功能以及嗅球体积和嗅沟深度的研究

发布时间：2018-04-01 17:38

本文选题：嗅觉障碍　切入点：嗅球　出处：《临床耳鼻咽喉头颈外科杂志》2015年05期

【摘要】：目的:分析阿尔茨海默病(AD)患者主观嗅觉功能以及嗅球体积、嗅沟深度与嗅觉功能的相关性。方法:选取AD患者(AD组)及健康受试者(对照组)各50例,应用TT嗅觉测试法检查所有受试者的嗅觉功能,并行头颅MRI扫描分析其嗅球体积、嗅沟深度。结果:AD组TT嗅觉识别阈分数(2.80±0.31)显著高于对照组(1.50±0.17),差异有统计学意义(P0.05)。左右两侧嗅球体积及平均嗅球体积AD组分别为(29.78±5.17)、(30.14±4.87)、(30.05±5.08)mm3,对照组分别为(36.65±4.08)、(36.56±4.12)、(36.46±4.11)mm3;2组比较均差异有统计学意义(均P0.01)。AD组与对照组左右两侧嗅沟深度均及平均嗅沟深度差异无统计学意义(均P0.05)。AD组嗅觉识别阈与平均嗅球体积呈负相关(r=-0.711,P0.05),嗅觉识别阈与平均嗅沟深度无相关性(r=-0.127,P0.05)。结论:AD患者嗅球体积减小,嗅沟深度不变;嗅觉功能与嗅球体积具有相关性,与嗅沟深度无关;认知障碍的严重程度与嗅觉减退的程度具有一致性;嗅觉功能减退可作为AD患者早期客观的诊断指标。
[Abstract]:Objective: to analyze the correlation between subjective olfactory function, olfactory bulb volume, olfactory groove depth and olfactory function in patients with Alzheimer's disease (AD).Methods: the olfactory function of all subjects was examined by TT olfactory test, and the volume of olfactory bulb and depth of olfactory sulcus were analyzed by MRI scan in each group (n = 50) and control group (n = 50).Results the score of TT olfactory recognition threshold in the control group was significantly higher than that in the control group (2.80 卤0.31), and the difference was statistically significant (P 0.05).The volume of olfactory bulb and the mean volume of olfactory bulb in AD group were 29.78 卤5.17, 30.14 卤4.87, 30.05 卤5.08, respectively, while those in control group were 36.56 卤4.12, 36.46 卤4.11mm, respectively. There was no significant difference between P0.01).AD group and control group in olfactory sulcus depth and average olfactory sulcus depth.In P0.05).AD group, the olfactory recognition threshold was negatively correlated with the mean olfactory bulb volume, while the olfactory recognition threshold was not correlated with the mean olfactory groove depth.Conclusion the volume of olfactory bulb decreases and the depth of olfactory sulcus remains unchanged in the patients with head AD, the olfactory function is correlated with the volume of olfactory bulb and has no relation with the depth of olfactory sulcus, the severity of cognitive impairment is consistent with the degree of olfactory decline.Hypoolfactory function can be used as an early objective diagnostic index in AD patients.
【作者单位】：天津市环湖医院耳鼻咽喉科;
【分类号】：R749.16

【参考文献】