奥氮平对儿童精神分裂症患者糖脂代谢、肝功能及泌乳素的影响

发布时间：2018-04-03 23:18

本文选题：奥氮平　切入点：精神分裂症　出处：《重庆医学》2017年09期

【摘要】：目的探讨奥氮平对儿童精神分裂症(COS)患者糖脂代谢、肝功能及泌乳素水平的影响,为临床用药提供参考。方法选取38例COS患者(13~17岁)进行为期至少2周的奥氮平治疗,比较治疗前、后患者的体质量、丙氨酸氨基转氨酶(ALT)、天门冬酸氨基转氨酶(AST)、总胆固醇(TC)、三酰甘油(TG)、血糖(GLU)、泌乳素(PRL)的变化。结果服药治疗后患儿的体质量明显增加,平均增加(3.50±1.90)kg(P0.01)。治疗后患儿的ALT、AST、TC、TG、PRL均高于治疗前(P0.05)。但是治疗前、后血糖比较差异无统计学意义(P=0.598)。治疗前后体质量的变化与ALT、AST水平呈正相关(r=0.366、0.377,P0.05);而治疗前、后患儿的PRL与体质量的改变则呈负相关(r=-0.432,P0.01)。结论奥氮平可以导致COS患者的体质量增加,ALT、AST、TC、TG、PRL水平升高。
[Abstract]:Objective to investigate the effects of olanzapine on glucose and lipid metabolism, liver function and prolactin level in children with schizophrenia.Methods 38 COS patients aged 1317 years were treated with olanzapine for at least 2 weeks.The changes of alanine aminotransferase (alt), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TGN), blood glucose (GLU), prolactin (PRL).Results after taking medicine, the body weight of the children increased obviously, and the average increase was 3.50 卤1.90 kg / kg P 0.01g / L.After treatment, the PRL of the patients with alt ASTN TGG was higher than that of the patients before treatment (P 0.05).However, there was no significant difference in blood glucose before and after treatment (P < 0. 598).Before and after treatment, there was a positive correlation between the changes of body mass and the level of alt AST, and a negative correlation between the changes of PRL and body mass before and after treatment, and a negative correlation between the changes of PRL and body weight before and after treatment.Conclusion olanzapine can increase the body mass of patients with COS.
【作者单位】：郑州大学第一附属医院药学部;
【分类号】：R749.3

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