一个能够显示精神神经疾病患者空间工作记忆能力以及注意力缺陷的新测试

发布时间：2018-04-05 02:20

本文选题：空间工作记忆　切入点：注意力　出处：《上海交通大学》2013年硕士论文

【摘要】：精神分裂症(Schizophrenia, SZ)以及抑郁症(Major Depressive Disorder, DE)等神经精神疾病患者常表现出空间工作记忆能力以及注意力的显著下降。对于患者空间工作记忆能力以及注意力方面能力的判断和评价目前还主要依托于传统的一些测试以及医护人员的个人判断。通常传统的问答式的测试需要较长的时间，耗费了大量的人力物力且影响因素多，不可控因素大。为此，基于中国传统的九宫格，我们设计了一个新型测试，用以检测空间工作记忆能力以及注意力水平(Spatial Working Memory and Attention Test on Paired Symbols，SWAPS)。本测试由101道题目组成，全程持续仅几分钟。为验证本测试的准确性以及实用性，我们测试了59名精神分裂症患者、24名抑郁症患者以及130名精神健康的志愿者。本文中测试的相关的精神健康的志愿者年龄范围为12到60岁。我们按照年龄分段的测试结果分析显示，精神健康的人群在20-26岁时会出现空间工作记忆能力和注意力的巅峰阶段，而后随着年龄的增长，，这两项能力开始缓慢的下降。有趣的是，精神分裂症患者的测试结果分析显示，他们并没有呈现出与精神健康的正常人一样的神经发育高峰，也没有呈现出与正常人一样的随着年龄变化的趋势。并且在对于同龄的精神神经疾病患者(抑郁症和精神分裂症患者)和正常人的对比中，我们发现，成年的精神神经疾病患者的测试结果明显比正常人差，说明精神神经疾病的成年患者确实在空间记忆力以及注意力方面有一定功能上的缺失和伤害。
[Abstract]:Patients with neuropsychiatric disorders such as Schizophrenia (SZ) and Major Depressive Disorder (DED) often showed a significant decline in spatial working memory and attention.At present, the judgment and evaluation of patients' spatial working memory ability and attention ability are mainly based on some traditional tests and personal judgment of medical staff.The traditional question-and-answer test usually takes a long time, consumes a lot of manpower and material resources, has a lot of influence factors, and has a lot of uncontrollable factors.Therefore, based on the traditional H5 home page in China, we designed a new type of test to detect spatial Working Memory and Attention Test on Paired symbols.This test consists of 101 questions and lasts only a few minutes.To verify the accuracy and practicability of this test, we tested 59 schizophrenics and 24 depression patients and 130 mental health volunteers.The relevant mental health volunteers tested in this paper ranged in age from 12 to 60 years.Our age-disaggregated analysis showed that mentally healthy people experienced peak levels of spatial working memory and attention at the age of 20-26, and then began to decline slowly as they grew older.Interestingly, an analysis of the results of tests in schizophrenic patients showed that they did not exhibit the same neurodevelopmental peaks as healthy people, nor did they show the same trends as normal people with age.And in comparison of the same age patients with psychiatric disorders (depression and schizophrenia) and normal people, we found that adults with psychiatric disorders had significantly worse test results than normal people.It shows that adult patients with mental neuropathy do some functional impairment and injury in spatial memory and attention.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749

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