精神分裂症患者及其未患病父母的脑皮层影像学研究

发布时间：2018-04-09 13:42

本文选题：精神分裂症　切入点：磁共振成像　出处：《中国神经精神疾病杂志》2014年03期

【摘要】：目的探讨精神分裂症患者及其未患病父母脑皮层形态的改变。方法纳入精神分裂症患者33例及其未患病生物学父母63名,招募对照组1(30名)与对照组2(28名)分别与患者组和父母组对照。采集高分辨率结构头颅磁共振成像数据,通过FreeSurfer软件计算脑皮层体积、厚度、表面积、曲率及数个皮层下结构体积,分别比较患者组和父母组与各自对照组间的差异。结果患者组左半球前扣带回中部、枕中回、岛下沟、枕颞沟外侧,右半球枕颞回外侧、颞中回、岛上沟、颞下沟和双侧半球后扣带回背侧、颞上沟脑区皮层厚度较对照组1下降(均P6.0×10-4,经Bonferroni校正);协方差分析示父母组与对照组2相比,左半球近中央沟、额下回三角区、额中回、枕极、脑岛环状沟上段、额下沟、枕中及月状沟、眶沟外侧,以及右半球枕中回、外侧裂后段、中央前回下部脑区皮层厚度下降(均P0.05),但经多重比较校正后组间差异均无统计学意义(均P6.0×10-4)。结论皮层厚度可作为精神分裂症患者皮层形态改变的特异性指标,并存在一定的遗传性。
[Abstract]:Objective to investigate the changes of cerebral cortex in schizophrenic patients and their parents.Methods 33 schizophrenic patients and 63 non-diseased biological parents were enrolled in the study. The control group (30 patients) and the control group (228 patients) were compared with the patient group and the parent group.The volume, thickness, surface area, curvature and several subcortical structure volumes of cerebral cortex were calculated by FreeSurfer software. The difference between the patient group and the parent group and the control group was compared.Results the left hemisphere anterior cingulate gyrus, middle occipital gyrus, inferior island sulcus, lateral occipital temporal sulcus, lateral occipital temporal gyrus, middle temporal gyrus, island sulcus, inferior temporal sulcus and bilateral posterior cingulate gyrus were found in the patients group.The cortical thickness of the superior temporal sulcus was lower than that of the control group (all P6.0 脳 10-4, corrected by Bonferroni, and covariance analysis showed that the left hemispheric proximal central sulcus, inferior frontal gyrus triangle region, middle frontal gyrus, occipital pole, superior segment of the annular sulcus of the cerebral island, inferior frontal sulcus, and inferior frontal sulcus in the left hemispheres were lower than those in the control group 2.The cortical thickness of the middle occipital sulcus, the lateral orbital sulcus, the middle occipital gyrus of the right hemisphere, the posterior segment of the lateral fissure and the lower part of the precentral gyrus decreased (all P 0.05), but there was no significant difference between the two groups after multiple comparison and correction (all P 6.0 脳 10 ~ (-4)).Conclusion the cortical thickness can be used as a specific index of cortical morphologic changes in schizophrenic patients, and there is a certain degree of heredity.
【作者单位】：北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学);中国科学院心理研究所功能连接组与发展实验室行为科学重点实验室磁共振研究中心;北京大学第三医院放射科;
【分类号】：R749.3

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