基于格兰杰因果的精神分裂感觉门控P50脑网络研究

发布时间：2018-04-12 09:38

本文选题：精神分裂 + 格兰杰因果分析　；参考：《航天医学与医学工程》2017年03期

【摘要】：目的从多通道脑电的功能连接角度,研究精神分裂患者在感觉门控状态下的脑网络连接特性。方法采集10例精神分裂症患者和10例正常受试者的听觉条件测试范式下的脑电数据,利用基于频域格兰杰因果分析的定向传递函数计算各导联间的因果连接矩阵,构建出各频段的功能网络。计算每位受试者的信息流增益并运用图论的方法比较了两组间的差异。结果在high-beta和gamma频段,精神分裂组的DTF_(mean)显著高于对照组(P0.001),精神分裂组的聚类系数显著高于对照组(high-beta,P0.001;gamma,P0.01),精神分裂组的全局效率显著高于对照组(P0.001),精神分裂组的信息流增益与对照组相比存在差异。结论精神分裂患者在感觉门控过程中因果网络在high-beta和gamma频段存在着过连接现象,表明脑区间的连接出现异常。
[Abstract]:Objective to study the characteristics of brain network connection in patients with schizophrenia in sensory gated state from the angle of functional connection of multichannel EEG.Methods EEG data were collected from 10 schizophrenic patients and 10 normal subjects under the auditory condition test paradigm. The causal connection matrix between the leads was calculated by the directional transfer function based on frequency domain Granger causality analysis.The functional network of each frequency band is constructed.The information flow gain of each participant was calculated and the differences between the two groups were compared using graph theory.Results in the high-beta and gamma bands,In schizophrenia group, the mean of DTF was significantly higher than that of control group (P 0.001), the clustering coefficient of schizophrenia group was significantly higher than that of control group (P 0.001), the global efficiency of schizophrenia group was significantly higher than that of control group (P 0.001), and the information flow gain of schizophrenia group was significantly higher than that of control group.Conclusion the causal network in the sensory gating process of schizophrenic patients is over-connected in the high-beta and gamma bands, which indicates the abnormal connections between the brain regions.
【作者单位】：天津医科大学生物医学工程与技术学院;北京回龙观医院;
【基金】：国家自然科学基金(61175118) 国家教育部留学回国人员科研启动基金(20111568) 天津市自然科学基金(12JCYBJC19500) 北京市自然科学基金(7162087)
【分类号】：R749.3

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