精神分裂症伴发2型糖尿病与烟碱型乙酰胆碱受体基因多态性关联研究

发布时间：2018-04-12 18:49

本文选题：精神分裂症 + 型糖尿病　；参考：《中国神经精神疾病杂志》2017年08期

【摘要】：目的在中国汉族精神分裂症患者中探讨烟碱型乙酰胆碱受体基因多态性与2型糖尿病共病的关联。方法采用Taq Man荧光探针基因分型技术对346例伴发2型糖尿病的中国汉族精神分裂症患者和360例不伴糖尿病的精神分裂症患者的α3、α4、α7、α5烟碱型乙酰胆碱受体(neuronal nicotinic acetylcholine receptor,n Ach R)基因即CHRNA3(rs1317286)、CHRNA4(rs1044396)、CHRNA7(rs6494212)及CHRNA5(rs16969968、rs684513)多态位点进行基因分型,比较等位基因频率和基因型频率,并进一步进行基因-基因交互作用分析。结果单位点分析显示男性患者rs6494212位点的等位基因分布和基因型分布在两组间差异均有统计学意义(P0.05);rs1317286、rs1044396、rs16969968、rs684513位点的基因型分布和等位基因分布均无明显差异(P均0.05)。CHRNA5基因的两个单核苷酸多态位点(single nucleotide polymorphisms,SNPs)组成的单体型与两组疾病共病关联无统计学意义(P0.05)。进一步基因交互作用分析显示rs131726、rs1044396、rs6494212及rs684513这4个位点的联合作用模式可能与两组疾病共病相关(P=0.002)。结论 CHRNA7(rs6494212)可能是中国汉族男性精神分裂症患者患2型糖尿病的易感基因。rs1317286、rs1044396、rs6494212及rs684513位点的联合作用可能与精神分裂症共病2型糖尿病相关。
[Abstract]:Objective to investigate the association between nicotinic acetylcholine receptor (nicotinic acetylcholine receptor) gene polymorphism and type 2 diabetes mellitus (T2DM) in Chinese patients with schizophrenia.Methods the 伪 3, 伪 4, 伪 7, 伪 5 nicotinic acetylcholine receptor neuronal nicotinic acetylcholine receptor Ach in 346 Chinese Han patients with type 2 diabetes mellitus and 360 schizophrenic patients without diabetes mellitus were detected by Taq Man fluorescence probe genotyping technique.The polymorphic loci of CHRNA3 rs1317286 (CHRNA4rs1044396) and CHRNA5 (rs16969968rs684513) were genotyped.Allele frequency and genotype frequency were compared, and gene-gene interaction was further analyzed.Results the allelic distribution and genotype distribution of rs6494212 locus in male patients were significantly different between the two groups. There was no significant difference in genotype distribution and allele distribution of 0.05).CHRNA5 gene at rs1044396rs16969968 rs684513 between the two groups.The haplotypes composed of two single nucleotide polymorphisms (SNPs) were not associated with two groups of disease syndromes (P 0.05).Further gene interaction analysis showed that the combined action patterns of rs131726, rs1044396, rs6494212 and rs684513 might be related to the two groups of diseases.Conclusion CHRNA7rs6494212) may be associated with type 2 diabetes mellitus in Chinese male schizophrenic patients. Rs1317286rs1044396rs6494212 and rs684513 locus may be associated with type 2 diabetes mellitus.
【作者单位】：复旦大学附属中山医院心理医学科;上海交通大学医学院附属新华医院临床心理科;上海交通大学医学院附属精神卫生中心遗传实验室;上海交通大学医学院附属精神卫生中心上海市重性精神病重点实验室;
【基金】：上海交通大学医学院转化医学协同创新中心项目(编号:TM201506,TM201624)
【分类号】：R587.1;R749.3

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