喹硫平联合丙戊酸钠对首发性精神分裂症伴有冲动与攻击行为患者兴奋躁动的影响

发布时间：2018-04-13 07:25

本文选题：喹硫平 + 丙戊酸钠　；参考：《东南大学学报(医学版)》2015年04期

【摘要】：目的:探讨喹硫平联合丙戊酸钠对缓解伴有冲动及攻击行为的首发精神分裂症患者兴奋躁动的疗效及可能存在的药物不良反应。方法:采用随机分组法,将我院84例伴有攻击行为的首发精神分裂症患者分为合并用药组(喹硫平加丙戊酸钠)及单独用药组(喹硫平),比较两组患者在治疗6周内其外显行为量表、阳性症状和阴性症状量表、阳性症状量表、阴性症状量表、副反应量表及不良反应发生率上的差异。结果:84例病例中脱落3例,实际参与研究81例;其中由外显行为量表结果可知,两组患者治疗2周后症状均有所好转(t合并用药组=6.241,t单独用药组=4.352,P0.01),但在治疗4周两组间疗效出现一定差异,且合并用药组优于单独用药组(t4周=9.324,t6周=13.24,P0.01);而阳性症状和阴性症状量表结果同样显示,随着治疗时间的加长,合并用药组的治疗效果要优于单独用药组(F=9.543,P0.05);另外,两组不同治疗时间点上阳性症状量表同样存在差异(t4周=9.295,t6周=10.342,P0.01);此外,由副反应量表(TESS)及不良反应情况可知,两组患者不良反应发生率差异无统计学意义,且TESS评分仅在用药2周后出现过差异(t=4.147,P0.05)。结论:对伴有攻击行为的首发精神分裂症患者给予喹硫平联合丙戊酸钠相较于单独使用喹硫平,前者疗效显著,且两者的不良反应发生情况相当。
[Abstract]:Aim: to investigate the effect of quinalapine combined with valproate on the remission of agitation and agitation in patients with first episode schizophrenia with impulsive and aggressive behavior and possible adverse drug reactions.Methods: a randomized grouping method was used.84 first-episode schizophrenia patients with aggressive behavior in our hospital were divided into two groups: the combined treatment group (quetiapine plus valproate sodium) and the single medication group (quetiapine). The explicit behavior scales were compared between the two groups within 6 weeks of treatment.Positive and negative symptom scale, positive symptom scale, negative symptom scale, side effect scale and adverse reaction rate.Results among 84 cases, 3 cases dropped out and 81 cases participated in the study.After 2 weeks of treatment, the symptoms of the two groups were improved, but there were some differences between the two groups after 4 weeks of treatment.The results of positive and negative symptom scale also showed that the therapeutic effect of the combined treatment group was better than that of the single drug group with the prolongation of the treatment time. In addition, the treatment effect of the combined medication group was better than that of the single drug group. In addition, the positive and negative symptoms scale also showed that the treatment effect of the combined drug group was better than that of the single drug group with the prolonging of the treatment time; in addition, the treatment effect of the combined drug group was better than that of the single drug group.There was also significant difference in the positive symptom scale between the two groups at different treatment time points, and there was no significant difference in the incidence of adverse reactions between the two groups according to the side effects scale (TESS) and adverse reactions.The TESS score was different only 2 weeks after treatment.Conclusion: quetiapine combined with valproate in first-episode schizophrenic patients with aggressive behavior is more effective than quinalapine alone, and the adverse reactions of the two groups are similar.
【作者单位】：华中科技大学同济医学院附属精神卫生中心;
【分类号】：R749.3

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