氨磺必利对老年抑郁症患者事件相关电位P300的影响

发布时间：2018-04-14 10:14

本文选题：阿米舒必利 + 老年期抑郁症　；参考：《中国老年学杂志》2016年02期

【摘要】：目的探讨氨磺必利对老年抑郁症患者事件相关电位P300的影响。方法采用随机开放对照研究,将60例老年抑郁症患者分为单纯应用西肽普兰治疗组(研究组1,n=30)及氨磺必利联合西肽普兰治疗组(研究组2,n=30),选择30例健康者作为对照组。研究组1、2治疗8 w前后予《汉密尔顿抑郁量表》(HAMD)评分,各组分别检测P300,并比较P300潜伏期及波幅的差异。采用Asberg抗抑郁剂副反应量表(SERS)评定两组药物副反应。结果治疗前,研究组1、研究组2 P300潜伏期均比对照组延长,波幅均比对照组降低(P0.05,P0.01);治疗后,实验组2 P300潜伏期比治疗前缩短,波幅均比治疗前升高(P0.05,P0.01);显效率及总有效率明显高于实验组1(P0.01),但两组SERS评分无统计学差异(P0.05)。结论氨磺必利具有改善老年抑郁症患者认知功能的作用。
[Abstract]:Objective to investigate the effect of amsulfuropride on event-related potential P 300 in elderly patients with depression.Methods Sixty patients with senile depression were randomly divided into two groups: the control group (n = 30) and the control group (n = 30). The control group was divided into two groups: the control group (n = 30) and the control group (n = 30).The study group was treated with Hamilton Depression scale (Hamilton Depression scale) before and after 8 weeks of treatment. P300 was measured in each group, and the latency and amplitude of P300 were compared.The side effects of two groups were evaluated by Asberg antidepressant side effects scale (SERS).Results before treatment, the latency of 2P300 in the study group was longer than that in the control group, and the amplitude was lower than that in the control group, and after treatment, the latency of 2P300 in the experimental group was shorter than that before treatment.The amplitudes of the two groups were significantly higher than those before treatment, and the significant and total effective rates were significantly higher than those of the experimental group, but there was no significant difference in SERS scores between the two groups (P 0.05).Conclusion amsulfuropride can improve cognitive function in elderly patients with depression.
【作者单位】：南京医科大学附属无锡精神卫生中心精神科;
【基金】：江苏省自然基金面上项目课题(BK2012545)
【分类号】：R749.4

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