脑白质疏松对遗忘型轻度认知障碍患者认知功能和日常生活能力的影响

发布时间：2018-04-14 19:26

本文选题：遗忘型轻度认知障碍 + 认知功能　；参考：《临床神经病学杂志》2017年05期

【摘要】：目的研究脑白质疏松对遗忘型轻度认知障碍患者(a MCI)认知功能和日常生活能力的影响。方法对67例a MCI患者(a MCI组)和71名正常志愿者(正常对照组)进行临床资料采集。采用MMSE、Mattis痴呆评定量表(MDRS)、听觉词语学习记忆量表(AVLT)和日常生活能力评估量表(ADL)分别评估受试者认知功能和日常生活能力。采用Fazekas评分方法对脑室旁白质高信号(PVH)和深部白质高信号(DWMH)独立评分。结果 a MCI组ADL评分、PVH评分和DWMH评分均显著高于正常对照组(均P0.05)。a MCI组MMSE评分、MDRS-总分、MDRS-起始/保持评分、MDRS-概念形成评分、MDRS-记忆评分、AVLT-短延迟记忆评分、AVLT-长延迟记忆评分均明显低于正常对照组(均P0.05)。多元逐步回归分析结果显示,MDRS-起始/保持评分为a MCI组患者ADL评分的影响因素(β=-0.743,P0.05)。年龄和DWMH评分分别为a MCI组患者MDRS-起始/保持评分的影响因素(β=-0.662,P0.05;β=-0.228,P0.05)。结论 a MCI患者深部脑白质疏松越严重、年龄越大,其执行功能损害越严重,可导致日常生活能力下降。
[Abstract]:Objective to study the effects of leukoaraiosis on cognitive function and ADL in amnesia patients with mild cognitive impairment.Methods Clinical data were collected from 67 patients with a MCI and 71 normal volunteers (normal control group).The subjects' cognitive function and ADL were evaluated by MMSE Mattis dementia scale (MMSE Mattis dementia scale), auditory word learning and memory scale (AVLTL) and ADL scale (ADL).The Fazekas score was used to evaluate the ventricular white matter hyperintensity (PVH) and deep white matter hyperintensity (DWMH).Results the ADL scores and DWMH scores in a MCI group were significantly higher than those in the normal control group (P0.05. 0. 05%. A MCI group). MMSE score and MDRS- onset / retention score were significantly higher than those in the normal control group (P < 0. 05).The amnesia score was significantly lower than that in the normal control group (P 0.05).Multiple stepwise regression analysis showed that MDRSs-onset / retention score was the influencing factor (尾 -0.743g / P0.05) in patients with a MCI group.Age and DWMH score were the influencing factors of MDRS-onset / maintenance score (尾 -0.662n P0.05; 尾 -0.228g / P0.05) in a MCI group.Conclusion the more serious and older the patients with a MCI are, the more serious the executive function is, which can lead to the decline of daily living ability.
【作者单位】：青海省第三人民医院精神科;南京医科大学附属脑科医院老年精神科;
【基金】：国家自然科学基金(81571314,81371474,91132727) 江苏省“六大人才高峰”项目(2015-WSN-071) 南京市医学科技发展项目(YKK15108) 南京市科技局国际联合研发(201505001)
【分类号】：R749.1

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