深部脑磁刺激术对慢性束缚应激大鼠习得性无助样绝望行为的疗效

发布时间：2018-04-16 09:02

本文选题：慢性束缚应激 + 习得性无助样绝望行为　；参考：《中国康复理论与实践》2017年02期

【摘要】：目的探讨深部脑磁刺激术(DMS)对慢性束缚应激(CRS)大鼠模型习得性无助样绝望行为的治疗作用。方法 29只Sprague-Dawley大鼠随机分为对照组(n=8)和CRS组(n=21)。CRS组予以束缚应激,对照组不做任何应激处理。3周后,通过强迫游泳实验(FST)观察大鼠习得性无助样绝望行为,将具有绝望行为的CRS组大鼠随机分为假治疗组(n=6)、DMS组(n=8)和西酞普兰组(n=7),并接受相应治疗。1周后,观察各组在FST中的不动时间。结果 CRS组在FST中不动时间明显高于对照组(F=11.260,P=0.002)。治疗1周后,西酞普兰组FST中的不动时间无显著性差异(F=1.565,P=0.235);DMS组不动时间短于假治疗组(F=5.560,P=0.036),也短于治疗前(F=6.277,P=0.025)。结论 CRS可导致大鼠产生习得性无助样绝望行为,为期1周DMS治疗可改善该行为。
[Abstract]:Objective to investigate the therapeutic effect of deep brain magnetic stimulation (DMSs) on learning helplessness in chronic restraint stress (CRS) rats.Methods Twenty-nine Sprague-Dawley rats were randomly divided into control group (n = 8) and CRS group (n = 21). The control group was subjected to restraint stress, and the control group was not treated with any stress for 3 weeks.The rats in the CRS group with desperate behavior were randomly divided into two groups: the sham treatment group and the citalopram group. After 1 weeks of treatment, the time of immobility in FST was observed.Results the time of immobility in FST in CRS group was significantly higher than that in control group.After 1 week of treatment, there was no significant difference in the immobility time in FST of citalopram group.Conclusion CRS can induce learning hopelessness in rats, and DMS therapy for one week can improve the behavior.
【作者单位】：首都医科大学神经生物学系;首都医科大学北京脑重大疾病研究院;北京澳丹斯生物科技有限公司;
【基金】：国家自然科学基金面上项目(No.81671345;No.31171032;No.31271154) 北京市自然科学基金重点项目(No.7091002);北京市自然科学基金重点B类项目(No.KZ201610025026)
【分类号】：R749

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