坦度螺酮联合帕罗西汀治疗老年性抑郁症的有效性与安全性

发布时间：2018-04-17 03:41

本文选题：坦度螺酮 + 帕罗西汀　；参考：《医药导报》2014年11期

【摘要】：目的观察坦度螺酮联合帕罗西汀治疗老年性抑郁症的有效性和安全性。方法 120例起病年龄≥60岁的抑郁症患者,按随机数字表法分为治疗组和对照组各60例。均给予帕罗西汀20 mg·d-1,po;治疗组加用枸橼酸坦度螺酮10 mg,tid,po。治疗前及治疗后第1,2,4,8周评定汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA);治疗前及治疗后第1,2,4,8周查血常规、尿常规、肝功能、肾功能、心电图。以HAMD、HAMA减分率作为疗效评定指标。结果治疗组第1周HAMD、HAMA开始逐步下降,对照组治疗第2周开始逐步下降,两组8周HAMD、HAMA减分差异有统计学意义(P0.05),总有效率差异有统计学意义(P0.05)。两组恶心、便秘等常规不良反应差异无统计学意义。结论坦度螺酮联合帕罗西汀能快速、有效地缓解老年性抑郁症的抑郁和焦虑症状。
[Abstract]:Objective to observe the efficacy and safety of tandoproxone combined with paroxetine in the treatment of senile depression.Methods 120 patients with depression aged more than 60 years were divided into treatment group (n = 60) and control group (n = 60).All patients were treated with paroxetine 20 mg / d and the treatment group with 10 mg / d of tendobroxone citrate.Before and after treatment, Hamilton Depression scale (Hamd) and Hamilton anxiety scale (Hamilton anxiety scale) were evaluated before and 8 weeks after treatment. Blood routine examination, urine routine examination, liver function, renal function and electrocardiogram were examined before and after treatment.The score reduction rate of Hama was used as the evaluation index of curative effect.Results HAMD-Hama began to decrease gradually in the first week in the treatment group and gradually in the control group at the second week of treatment. There was a significant difference in the score of HAMD-Hama between the two groups at the 8th week (P 0.05), and the total effective rate was significantly different from that of the control group (P 0.05).There was no significant difference in routine adverse reactions such as nausea and constipation between the two groups.Conclusion Tanduspirone combined with paroxetine can relieve depression and anxiety of senile depression quickly and effectively.
【作者单位】：浙江省湖州市第三人民医院老年精神科;
【分类号】：R749.4

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