儿童注意缺陷多动障碍成年早期不同结局患者的工作记忆

发布时间：2018-04-17 17:20

本文选题：注意缺陷多动障碍 + 成年早期　；参考：《中国心理卫生杂志》2014年06期

【摘要】：目的:探讨儿童注意缺陷多动障碍(ADHD)成年早期不同结局患者的工作记忆特点。方法:选取64例符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的ADHD儿童在成年早期(参加本研究时年龄18~24岁)进行随访。依据Conners'成人ADHD诊断会谈定式问卷评定成年早期ADHD的不同结局,对其中的28例成人ADHD患者及21例缓解者以及26例性别、智商匹配的正常成人采用不同工作记忆负荷(0-back、1-back、2-back)的n-back任务测查工作记忆特点,比较成年早期不同结局的ADHD患者在完成任务时的反应时(RT)、正确率和个体内反应时标准差(ISD)。结果:三组被试在完成三种工作记忆负荷的n-back任务时,其RT及ISD均随工作记忆负荷增加而增大(P0.001),而正确率则随工作记忆负荷增加而减小(P0.001),呈现等级变化规律;成人ADHD患者执行n-back任务时RT均长于缓解组[(507.7±79.7)ms vs.(454.8±65.9)ms,P0.01]和正常成人组[(507.7±79.7)ms vs.(446.6±52.4)ms,P0.01],ISD均大于缓解组[(164.4±33.1)ms vs.(142.4±40.9)ms,P0.05]和正常成人组[(164.4±33.1)ms vs.(141.3±32.2)ms,P0.05];成人ADHD缓解者和正常成人执行n-back任务时RT、正确率和ISD之间差异无统计学意义。结论:成人ADHD患者可能仍存在语言工作记忆能力损害,而成人ADHD缓解者的语言工作记忆能力改善至正常水平,提示发育过程中ADHD的缓解可能与额叶功能有关的执行功能的改善有关。
[Abstract]:Objective: to investigate the working memory characteristics of children with ADHD with different outcomes in early adulthood.Methods: a total of 64 children with ADHD who met the diagnostic criteria of DSM-IV4 of the American Handbook for diagnosis and Statistics of Mental Disorder were followed up in their early adulthood (1824 years of age at the time of taking part in this study).According to Conners' Adult ADHD Diagnostic interview questionnaire, 28 adult ADHD patients, 21 remission patients and 26 genders were evaluated for different outcomes of ADHD in early adulthood.The working memory characteristics of normal adults matched with intelligence quotient were measured by n-back task with different working memory loads (0 backpack 1 backpack 2-back2). The response time of ADHD patients with different outcomes in early adulthood was compared. The correct rate and the standard deviation of intra-individual response time were compared.Results: the RT and ISD increased with the increase of working memory load, while the correct rate decreased with the increase of working memory load.The RT of n-back task in adult ADHD patients was significantly longer than that in remission group (507.7 卤79.7)ms vs.(454.8 卤65.9 vs.(454.8 P0.01) and normal adult group (507.7 卤79.7)ms vs.(446.6 卤52.4 ADHD P0.01), which was higher than that in remission group [164.4 卤33.1)ms vs.(142.4 卤40.9 vs.(142.4 卤40.9 vs.(142.4] and normal adult group (164.4 卤33.1)ms vs.(141.3 卤32.2msP 0.05).There was no statistical significance.Conclusion: there may still be language working memory impairment in adult ADHD patients, while the language working memory ability of adult ADHD remission patients is improved to normal level.The results suggest that the remission of ADHD during development may be related to the improvement of executive function related to frontal lobe function.
【作者单位】：北京大学第六医院;北京大学精神卫生研究所;卫生部精神卫生学重点实验室(北京大学);
【基金】：973项目子课题(2014CB846104) 国家自然科学基金(81371496,30970802)
【分类号】：R749.94

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