抑郁障碍和焦虑障碍治疗的神经心理机制——脑成像研究的ALE元分析

发布时间：2018-04-18 02:17

本文选题：抑郁障碍 + 焦虑障碍　；参考：《心理学报》2017年10期

【摘要】：抑郁障碍和焦虑障碍是两种最常见的精神障碍。使用激活似然估计(activation likelihood estimation,ALE)元分析对抑郁和焦虑障碍患者治疗后出现的一致脑区激活改变进行评估,并考察不同条件下这一改变的差异。研究共纳入25篇文献,结果发现:(1)抑郁和焦虑障碍接受治疗后,枕下回(inferior occipital gyrus,IOG)等脑区激活增加;豆状核(lentiform nucleus)等激活减少。(2)a.心理治疗产生的脑激活改变为豆状核活动的减少;药物治疗则在于扣带回(cingulate gyrus)等活动增加,而楔前叶(precuneus)等活动减少。b.任务下成像治疗后激活增加的脑区为扣带回等,减少的脑区为楔前叶等;静息下成像,治疗后枕下回等激活增加,额内侧回(medial frontal gyrus,MFG)等激活减少。c.抑郁障碍治疗后的脑激活变化为扣带回等活动增加,楔前叶等活动减少;焦虑障碍在于前扣带回/额内侧回(anterior cingulate/MFG)活动减少。研究表明治疗会给抑郁和焦虑障碍带来一致的脑区激活改变;治疗方法、成像状态和障碍类型不同,治疗后脑区激活改变也存在差异。
[Abstract]:Depression and anxiety disorder are the two most common mental disorders.Activation likelihood estimation (Ale) element analysis was used to evaluate the changes of consistent brain activation in patients with depression and anxiety disorder after treatment, and to investigate the difference of this change under different conditions.25 articles were included in the study. The results showed that the activation of occipital gyrusus) and lentiform nucleusin the inferior occipital gyrus increased after the treatment of depression and anxiety disorder, and the activation of lentiform nucleus. was decreased in the lentiform nucleus of the lentiform nucleus of the inferior occipital gyrus.The changes of brain activation induced by psychotherapy were the decrease of lenticular nucleus activity, the increase of cingulate gyrus and the decrease of precuneus.b.The activation increased in cingulate gyrus and decreased in precuneal lobe after task imaging, but increased in resting imaging, and decreased in medial frontal gyrusus in medial frontal gyrus.The changes of brain activation after treatment with depression were increased in cingulate gyrus and decreased in anterior cuneal lobe, and the anxiety disorder was that anterior cingulate / medial frontal gyrus / anterior cingulate / MFG decreased.The research shows that the treatment can bring the same changes of brain activation to depression and anxiety disorder, and there are differences in the treatment methods, imaging status and type of disturbance after the treatment, there are also differences in the changes of brain area activation after treatment.
【作者单位】：福州大学人文社会科学学院应用心理学系;Department
【基金】：国家社科基金项目(16CSH051)资助
【分类号】：R749.4

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