罗通定联合曲唑酮治疗稽延性戒断症状的临床研究

发布时间：2018-04-21 09:03

本文选题：曲唑酮 + 罗通定　；参考：《中国临床药理学杂志》2014年04期

【摘要】：目的评价罗通定联合曲唑酮治疗阿片类物质依赖者稽延性戒断症状的临床疗效及安全性。方法将120例海洛因依赖者随机分成2组,试验组62例,对照组58例。2组患者均先经过东莨菪碱复合麻醉(杨氏1+1)脱毒治疗,待尿吗啡检测转阴性后,试验组给予罗通定联合曲唑酮治疗,对照组单纯给予曲唑酮治疗,2组疗程均为8周。治疗前与治疗2,4,6,8周后用稽延性戒断症状量表(PWSS),汉密尔顿焦虑量表(HAMA)进行评分分析,用不良反应症状量表(TESS)评价安全性。结果控制了吸食时间和剂量这2个变量以后,组效应和治疗时间效应:PWSS(F=792.23,P0.01;F=716.76,P0.01)、HAMA(F=125.47,P0.01;F=1873.08,P0.01),分析显示组别和治疗时间差异有统计学意义;同时组别和治疗时间之间有明显的交互效应,PWSS(F=61.43,P0.01)、HAMA(F=12.96,P0.01)。治疗8周后,试验组有效率为78%,对照组有效率为47%,2组比较差异有统计学意义(P0.05)。结论罗通定联合曲唑酮是一种疗效高,安全,耐受性好,无潜在药物成瘾性的治疗稽延性戒断症状的治疗方案。
[Abstract]:Objective to evaluate the efficacy and safety of rotunding combined with trazodone in the treatment of protracted withdrawal symptoms in opioid addicts. Methods 120 heroin addicts were randomly divided into two groups: the experimental group (n = 62) and the control group (n = 58). All the patients were treated with scopolamine combined anesthesia (Yang's 11). The experimental group was treated with rotundine combined with trazodone, while the control group was treated with trazodone alone for 8 weeks. The patients were evaluated with the protracted withdrawal symptom scale (PWSSN) and Hamilton anxiety scale (HAMA) before treatment and 8 weeks after treatment, and the safety was evaluated with the adverse reaction symptom scale (TESS). Results after the control of the two variables, the group effect and the therapeutic time effect: PWSSFU 792.23, P0.01F 716.76C, P0.01Hama 125.47, P0.01P0.01A, the analysis showed that the difference between group and treatment time was statistically significant, at the same time, there was a significant interaction between group and treatment time. At the same time, there was a significant interaction between group and treatment time (PWSSSSFU 61.43P0.01a) and Hama F12.96a (P0.01A). The results showed that there was a significant difference between the group and the time of treatment, and there was significant difference between the group and the treatment time, and there was a significant interaction between the group and the treatment time, and there was a significant interaction between the group and the treatment time. After 8 weeks of treatment, the effective rate in the experimental group was 78%, while that in the control group was 47%. The difference between the two groups was statistically significant (P 0.05). Conclusion rotundine combined with trazodone is a safe, safe and well tolerated treatment for protracted withdrawal symptoms without potential drug addiction.
【作者单位】：宁波戒毒研究中心;
【基金】：科技部“十二五”支撑项目(2012BAI01B07)
【分类号】：R749.6

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