难治性强迫症胶质细胞源性神经营养因子水平与认知功能

发布时间：2018-04-21 19:27

本文选题：难治性强迫症 + 胶质细胞源性神经营养因子　；参考：《中国神经精神疾病杂志》2015年08期

【摘要】：目的探讨难治性强迫症(obsessive-compulsive disorder,OCD)患者血清中胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)的浓度水平与认知功能之间的关系。方法纳入41例难治性强迫症患者和57名性别、年龄、受教育年限相匹配的正常对照作为研究对象,采用酶联免疫法测定血清中GDNF的浓度水平,采用Yale-Brown强迫量表(Yale-Brown obsessive-compulsive scale,Y-BOCS)评估患者强迫症状,用成套神经心理状态评估工具(repeatable battery for the assessment of neuropsychological status,RBANS)对患者组和对照组的认知功能进行评定。结果患者组血清GDNF水平低于对照组[(7.11±1.65)pg/m L vs.(9.16±2.14)pg/m L],差异有统计学意义(P0.01);认知功能方面,患者组语言功能比对照组差[(89.12±12.13)vs.(98.52±9.37)],差异具有统计学意义(P0.01)。难治性强迫症患者血清GDNF水平与性别、起病年龄、病程、Y-BOCS总分及RBANS总分无统计学相关性(P0.05)。结论难治性强迫症患者语言功能存在障碍,GDNF与强迫症的发生可能具有相关性。
[Abstract]:Objective to investigate the relationship between the level of glial cell line-derived neurotrophic factor (GDNF) and cognitive function in patients with obsessive-compulsive OCD (OCD) patients with obsessive-compulsive obsessive-compulsive disorder (OCD). Methods 41 patients with refractory obsessive-compulsive disorder (OCD) and 57 normal controls with sex, age and years of education were included as the study subjects. Serum GDNF levels were measured by enzyme-linked immunosorbent assay (Elisa). The obsessive-compulsive symptoms of patients were evaluated by Yale-Brown obsessive-compulsive obsessive-compulsive scale and repetitive battery for the assessment of neuropsychological statusRBANSwere used to evaluate the cognitive function of the patients and the control group. Results the serum GDNF level in the patients group was lower than that in the control group [7.11 卤1.65)pg/m L vs.(9.16 卤2.14)pg/m L], the difference was statistically significant (P0.01), and the cognitive function in the patients group was worse than that in the control group [89.12 卤12.13)vs.(98.52 卤9.37], the difference was statistically significant (P 0.01). There was no significant correlation between serum GDNF level and sex, onset age, total score of Y-BOCS and total score of RBANS in patients with refractory obsessive-compulsive disorder (P 0.05). Conclusion GDNF may be associated with the occurrence of obsessive-compulsive disorder in patients with refractory obsessive-compulsive disorder.
【作者单位】：江苏省检验医学重点实验室江苏大学医学院;江苏扬州五台山医院;
【基金】：扬州市2012科技攻关-社会发展科技攻关项目(编号:yzSGG-201230024)
【分类号】：R749

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