内分泌—免疫网络失衡与精神分裂症的相关性研究

发布时间：2018-04-23 01:25

  本文选题：精神分裂症 + 糖脂代谢　； 参考：《青岛大学》2016年硕士论文

【摘要】：目的通过对92例精神分裂症患者(SP组)和74名无严重躯体及免疫性疾病的健康对照者(HC组)染色体体型畸变(CA)率、微核(MN)发生率、IL-1α、IL-1β、IL-2、IL-6、IL-17、部分激素及血清糖脂代谢水平的观测,探讨内分泌-免疫网络失衡与精神分裂症的相关性,为精神分裂症的早期诊断、治疗及预后提供实验依据。方法1.基本信息及各项体征指数问卷调查及病理资料查询。2.全自动免疫分析仪化学发光微粒子免疫分析(CMIA)法检测HPT轴、HPA轴激素水平;酶联免疫(ELISA)法检测IL-1α、IL-1β、IL-2、IL-6、IL-17水平;外周血淋巴细胞CA实验、MN实验检测遗传物质损伤;全自动生化分析仪(酶法)检测糖、脂代谢水平。结果1.SP组各项体征指数及高血压患病率与HC组无明显差异;HDL明显低于、GLU、TG、TC、LDL显著高于HC组;LDL、HDL与病程分别呈正、负相关。2.SP组HPT轴激素中,T4水平明显高于HC组,且T4与病程、PANSS正相关(r=0.072,0.087;p均0.05);HPA轴激素中仅CORT水平明显高于HC组,且与PANSS(r=0.495,p0.05)正相关。3.两组IL-2、IL-6水平无明显差异(p0.05);SP组IL-1α、IL-1β、IL-17明显高于HC组,且IL-1α、IL-1β、IL-17无性别、城乡、精神疾病家族史差异,且与年龄不相关(p0.05),IL-1α、IL-1β与PANSS显著正相关(r=0.266,0.286;p均0.01),IL-17与总病程及PANSS分值正相关(r=0.459,0.228;p均0.05)。4.SP组染色体体型畸变(CA)率、微核(MN)发生率、CA与MN异常人数与HC组均无明显差异(p0.05)。结论1.HDL降低,LDL、T4、CORT增高,说明内分泌代谢紊乱与精神分裂症相关。2.精神分裂症病人未发现遗传物质的异常结构损伤。3.精神分裂症患者IL-1α、IL-1β、IL-17细胞因子增高;其中IL-17在精神分裂症的发生发展过程中起到重要的作用,在精神分裂症的早期诊断及疗效评价中具有一定参考价值。4.神经-内分泌-免疫网络失衡与精神分裂症发生密切相关,调控内分泌免疫紊乱对该病的治疗具有重要的意义。
[Abstract]:Objective to observe the rate of chromosome type aberration (CAA) and the incidence of MNs in 92 patients with schizophrenia (SP group) and 74 healthy controls without severe somatic and immunological diseases (HC group), and to observe the incidence of IL-1 伪, IL-1 尾, IL-2, IL-6, IL-17, some hormones and the level of serum glucose and lipid metabolism. To explore the relationship between endocrine immune network imbalance and schizophrenia, and to provide experimental basis for early diagnosis, treatment and prognosis of schizophrenia. Method 1. Basic information and physical signs index questionnaire and pathological information inquiry. 2. HPT axis hormone levels were detected by chemiluminescence microparticle immunoassay (CMIA), IL-1 伪 IL-1 尾 / IL-2IL-6 / IL-17 by enzyme linked immunosorbent assay (Elisa), and genetic material damage by peripheral blood lymphocyte CA assay (MN). The level of glucose and lipid metabolism was detected by automatic biochemical analyzer (enzymatic method). Results there was no significant difference between 1.SP group and HC group in the index of signs and the prevalence of hypertension. The level of T4 in HPT axis in 1.SP group was significantly higher than that in HC group, and the level of T4 in HPT axis of SP group was significantly higher than that in HC group. There was a positive correlation between T4 and PANSS, and there was a positive correlation between T4 and PANSS (P < 0.05). The level of only CORT in HPA-axis was significantly higher than that in HC group, and it was positively correlated with PANSS (0.495p0.05). There was no significant difference in the level of IL 2 and IL 6 between the two groups. The levels of IL 17 in IL-1 伪 and IL 1 尾 and IL 17 in SP group were significantly higher than those in HC group, and there were no gender differences in IL 2 尾 IL 17 between urban and rural areas and the family history of mental illness. In addition, there was a significant positive correlation between IL-1 尾 and PANSS with age independent (P < 0.05). The positive correlation between IL-17 and the total course of disease and the PANSS score were 0.4590.228p and 0.4590.228p respectively. There was no significant difference in the incidence of micronucleus MNs and the number of abnormal CA and MN in HC group (P 0.05). Conclusion 1.HDL decreased the increase of T 4 Cort, indicating that endocrine metabolic disorder is associated with schizophrenia. No abnormal structural damage of genetic material was found in schizophrenic patients. The levels of IL-1 伪, IL-1 尾 and IL-17 cytokines were increased in schizophrenic patients, in which IL-17 played an important role in the occurrence and development of schizophrenia, and had a certain reference value in the early diagnosis and evaluation of curative effect of schizophrenia. The imbalance of neuroendocrine and immune network is closely related to the occurrence of schizophrenia. The regulation of endocrine immune disorder is of great significance to the treatment of the disease.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R749.3
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本文编号：1789835