加味柴胡汤联合帕罗西汀对抑郁症患者血清炎症因子、生活质量及疗效的影响

发布时间：2018-04-24 04:38

本文选题：加味柴胡汤 + 帕罗西汀　；参考：《中华中医药学刊》2016年05期

【摘要】：目的:探讨加味柴胡汤联合帕罗西汀对抑郁症患者血清炎症因子、生活质量及疗效的影响。方法:本研究病例来源于医院于2013年5月—2015年5月收治的抑郁症患者90例,按照随机数字表法随机分为观察组45例与对照组45例。对照组采用帕罗西汀治疗,观察组在对照组基础上结合加味柴胡汤治疗。两组疗程均为8周。比较两组疗效、HAMD总分及各因子评分、血清炎症因子、生活质量评分及不良反应TESS评分。结果:观察组总有效率(91.11%)高于对照组(68.89%)(P0.05);两组认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑、情绪及HAMD总分治疗后明显下降(P0.05);观察组认知障碍、睡眠障碍、躯体性焦虑、精神性焦虑、情绪及HAMD总分治疗后明显低于对照组(P0.05);两组血清IL-2和TNF-α治疗后明显下降(P0.05);观察组血清IL-2和TNF-α治疗后低于对照组(P0.05);观察组生理功能、精神健康、躯体疼痛、生理职能、情感职能、生命活力、社会功能及总体健康评分治疗后高于对照组(P0.05);观察组治疗4周和8周TESS评分均明显低于对照组(P0.05)。结论:加味柴胡汤联合帕罗西汀对抑郁症患者疗效显著,可明显降低患者血清IL-2和TNF-α水平,提高患者生活质量。
[Abstract]:Objective: to investigate the effect of modified Chaihu decoction and paroxetine on serum inflammatory factors, quality of life and curative effect of depression patients. Methods: 90 patients with depression from May 2013 to May 2015 were randomly divided into observation group (n = 45) and control group (n = 45). The control group was treated with paroxetine, and the observation group was treated with modified Chaihu decoction on the basis of the control group. The course of treatment was 8 weeks in both groups. The total score of Hamd, the score of serum inflammatory factor, the score of quality of life and the score of TESS of adverse reaction were compared between the two groups. Results: the total effective rate of the observation group (91.11) was higher than that of the control group (68.89), the cognitive disorder, sleep disorder, somatic anxiety, mental anxiety, emotion and total score of HAMD were significantly decreased in the observation group (P 0.05), the cognitive disorder, sleep disorder and somatic anxiety in the observation group were significantly lower than those in the control group. After treatment, mental anxiety, emotion and total score of HAMD were significantly lower than those of control group (P0.05A), serum IL-2 and TNF- 伪 of two groups decreased significantly after treatment, serum IL-2 and TNF- 伪 of observation group were lower than that of control group (P0.05) after treatment, physiological function, mental health and somatic pain in observation group were lower than those in control group. The scores of physiological function, emotional function, life vigor, social function and overall health were higher than that of control group (P 0.05), and the TESS scores of observation group were significantly lower than that of control group at 4 and 8 weeks after treatment (P 0.05). Conclusion: Jiawei Chaihu decoction combined with paroxetine can significantly reduce the levels of serum IL-2 and TNF- 伪 in patients with depression and improve their quality of life.
【作者单位】：绍兴市第七人民医院;
【分类号】：R749.4

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